Origin of sympathetic and sensory innervation of the knee joint. A retrograde axonal tracing study in the rat.

Anatomy and Embryology
B Widenfalk, M Wiberg

Abstract

The origin of sympathetic and sensory innervation of the knee joint was investigated by the intra-axonal transport method. After injection of horseradish peroxidase (HRP) or horseradish peroxidase conjugated to wheat germ agglutinin (WGA-HRP) into the knee joint unilaterally in adult rats, labelled neurons were found ipsilaterally both in sympathetic and dorsal root ganglia at the lower thoracic and lumbosacral levels. A maximum of 1500 and 1000 peroxidase-positive cells were observed in the sympathetic and dorsal root ganglia, respectively; in the former they were mainly located at the levels of L2-L4, and in the latter mainly at L3-L5. The functional implications of the above observations are discussed in relation to pain mechanisms in joints and to the earlier hypothesis that a nervous component might be involved in the pathogenesis of chronic joint inflammation.

References

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Citations

Jan 1, 1990·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·B Widenfalk
Apr 1, 1991·The Anatomical Record·C HildebrandF Tuisku
Aug 15, 1993·Journal of Neuroscience Research·P T Salo, W G Tatton
Oct 30, 1995·The Journal of Comparative Neurology·M J GentleR J Sterling
Jul 15, 2006·The Journal of Physiological Sciences : JPS·Tomohiro NakayamaRyuzo Ito
Jun 30, 1992·Annals of the New York Academy of Sciences·T RendaC Casu
Jan 1, 1991·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·B Widenfalk
Jul 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P BumaA B Oestreicher
Jan 26, 2016·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Youngkyung KimYoung Wook Yooon

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