Origin of the avian neural crest

Stem Cells
M Bronner-Fraser

Abstract

Neural crest cells are derived from a population of multipotent stem cells within the neural tube. They emerge shortly after neural tube closure, migrate extensively in the embryo and localize in numerous sites, where they differentiate into neurons and glia of the peripheral nervous system, cartilage and bone of the face, melanocytes and various other cell types. This review summarizes recent experiments from our laboratory delineating the origin and lineage of avian neural crest cells. Neural crest cells arise from the ectoderm, which also gives rise to presumptive epidermal, placodal and neural tube cells. Fate mapping experiments have demonstrated that the neural crest arises at the juncture between presumptive epidermis and the neural plate. Inductive interactions between these two early tissues can generate neural crest cells, suggesting that signals travel through the epidermis to generate neural crest cells prior to neural tube closure. Injection of lineage tracer into individual cells reveals that a single neural fold can form all ectodermal derivatives (i.e., epidermis, neural tube, neural crest). Even after neural tube closure, neuroepithelial cells have the capacity to form multiple neural crest and neural tube deri...Continue Reading

References

Jan 1, 1979·Anatomy and Embryology·J Rollhäuser-ter Horst
Dec 1, 1989·Neuron·M Bronner-Fraser, S Fraser
Jan 1, 1994·Genes & Development·S TakadaA P McMahon
Dec 1, 1995·Developmental Biology·K B ArtingerM Bronner-Fraser
Oct 1, 1947·Biological Reviews of the Cambridge Philosophical Society·C L YNTEMA, W S HAMMOND
Jan 1, 1951·Journal of Morphology·V HAMBURGER, H L HAMILTON

❮ Previous
Next ❯

Citations

Jul 7, 1999·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·A J Kalyani, M S Rao
Feb 22, 2012·Journal of Visualized Experiments : JoVE·Shannon L Griswold, Peter Y Lwigale
Feb 14, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K-H SchäferP J Pasricha
Aug 24, 1999·Developmental Biology·T F CarlM W Klymkowsky
Aug 12, 1998·Developmental Biology·T MujtabaM S Rao
May 24, 2001·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·V E ElginA J Dwork

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.