Origin of various enzymes released from the substantia nigra and caudate nucleus: effects of 6-hydroxydopamine lesions of the nigro-striatal pathway

The Journal of Comparative Neurology
S A GreenfieldS G Shaw

Abstract

Various enzymes are released from the nigro-striatal pathway. The hypothesis that these enzymes--i.e., acetylcholinesterase, nonspecific cholinesterase, aminopeptidase, and lactate dehydrogenase--originate from dopaminergic nigro-striatal neurons was investigated. Following a 6-hydroxydopamine lesion of the rat nigro-striatal pathway, the spontaneous release of all four enzymes was reduced, in both the caudate nucleus and substantia nigra. In both structures the reduction in release of aminopeptidase and lactate dehydrogenase was less marked than that seen for acetylcholinesterase and nonspecific cholinesterase. In nonlesioned rats, application of 50 mM KCl to the substantia nigra led to an increase in enzyme release locally, accompanied by a decrease in release from the caudate nucleus. These changes were observed in release of acetylcholinesterase, aminopeptidase, and lactate dehydrogenase, but nonspecific cholinesterase remained unchanged. In rats with 6-hydroxydopamine lesions, nigral application of potassium no longer induced a significant decrease in release from the caudate nucleus in any of the enzymes. In perfusates of the treated group, however, a potassium-evoked increase in nigral aminopeptidase and lactate dehydrog...Continue Reading

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Citations

Feb 1, 1986·Journal of the Neurological Sciences·F J HuffR J Wurtman
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