Original evaluation of endothelial dysfunction in men with erectile dysfunction and metabolic syndrome

International Journal of Impotence Research
Sandro La VigneraAldo E Calogero

Abstract

We have recently demonstrated the diagnostic value of a new immunophenotype of blood endothelial progenitor cells (EPCs=CD45neg/CD34pos/CD144pos) and endothelial microparticles (EMPs=CD45neg/CD144pos/AnnexinVpos) in patients with arterial erectile dysfunction (ED) according to severity of cavernous arterial insufficiency evaluated through penile Doppler. The aim of this study was to evaluate both EPCs and EMPs in patients with arterial ED and metabolic syndrome (MetS), comparing these patients with another group of patients without MetS and ED and a third group with MetS but without ED. For this study 50 patients with arterial ED and MetS were selected (age: 55.0±3.0 years; range: 47-60). A group of age-matched (age: 54.0±2.0 years; range: 44-60) patients without arterial ED and MetS (n=30), and another group of age-matched (age: 57.0±4.0 years; range: 40-62) patients with MetS but without ED (n=20) represented the control groups. EPCs and EMPs were significantly higher in patients compared with other groups (P<0.01). Both EPCs and EMPs correlated positively with the age, body mass index, and score of international index of ED (version five items) and with the following cavernous artery indices: peak systolic velocity, accelera...Continue Reading

References

Jan 1, 1993·AJR. American Journal of Roentgenology·C B BensonM A Vickers
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·J-M Freyssinet
Aug 24, 2004·Circulation Research·Carmen Urbich, Stefanie Dimmeler
Sep 9, 2005·The New England Journal of Medicine·Nikos WernerGeorg Nickenig
Jun 1, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Tevfik DemirAdil Esen
Aug 11, 2006·International Journal of Impotence Research·K EspositoD Giugliano
Jan 12, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Olivier MorelFlorence Toti
Apr 16, 2008·The Journal of Sexual Medicine·Katherine EspositoDario Giugliano
Aug 2, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Karen K HirschiMervin C Yoder
Sep 11, 2008·Cardiovascular & Hematological Disorders Drug Targets·Carla RealSergio Dias
Dec 10, 2008·Endothelium : Journal of Endothelial Cell Research·Pietro DelvaEnrico Arosio
Dec 11, 2008·Vascular Health and Risk Management·Arun S Shet
Jan 12, 2012·Journal of Endocrinological Investigation·S La VigneraA E Calogero

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Citations

Apr 20, 2013·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Rosita A CondorelliSandro La Vignera

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