Origins and Evolution of the Primate Hepatitis B Virus.

Frontiers in Microbiology
Stephen LocarniniLilly Yuen

Abstract

Recent interest in the origins and subsequent evolution of the hepatitis B virus (HBV) has strengthened with the discovery of ancient HBV sequences in fossilized remains of humans dating back to the Neolithic period around 7,000 years ago. Metagenomic analysis identified a number of African non-human primate HBV sequences in the oldest samples collected, indicating that human HBV may have at some stage, evolved in Africa following zoonotic transmissions from higher primates. Ancestral genotype A and D isolates were also discovered from the Bronze Age, not in Africa but rather Eurasia, implying a more complex evolutionary and migratory history for HBV than previously recognized. Most full-length ancient HBV sequences exhibited features of inter genotypic recombination, confirming the importance of recombination and the mutation rate of the error-prone viral replicase as drivers for successful HBV evolution. A model for the origin and evolution of HBV is proposed, which includes multiple cross-species transmissions and favors subsequent recombination events that result in a pathogen and can successfully transmit and cause persistent infection in the primate host.

References

Oct 10, 1985·Nature·P TiollaisA Dejean
Dec 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Rodriguez-FriasJ Guardia
Apr 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K C Hyams
Jan 1, 1997·Journal of Molecular Evolution·M MizokamiT Gojobori
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·R E LanfordR Rico-Hesse
Jun 11, 1999·Journal of Virology·P Simmonds, D B Smith
Aug 10, 1999·Journal of Virology·K S WarrenE J Verschoor
Jan 21, 2000·The Journal of General Virology·L StuyverR Rossau
Jan 21, 2000·The Journal of General Virology·C HannounM Lindh
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·X HuB H Robertson
May 9, 2000·Journal of Virology·S GretheF T Hufert
Mar 21, 2001·The Journal of General Virology·P Simmonds
May 3, 2002·Reviews in Medical Virology·Betty H Robertson, Harold S Margolis
May 25, 2002·Journal of Molecular Evolution·Mario Ali Fares, Edward C Holmes
Aug 29, 2002·The Journal of Infectious Diseases·Charles HannounUNKNOWN Interpred trial group
Oct 22, 2002·The Journal of General Virology·Chaoyin CuiGengxi Hu
Aug 2, 2003·Gastroenterology·Chi-Jen ChuAnna S F Lok
Dec 23, 2003·Intervirology·Yuzo Miyakawa, Masashi Mizokami
Feb 11, 2004·The Journal of General Virology·Tran Thien-Tuan HuyKenji Abe
Mar 27, 2004·Molecular Biology and Evolution·Isabelle DupanloupGuido Barbujani
Apr 24, 2004·The Journal of General Virology·Gerald C KimbiMichael C Kew
May 6, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fuminaka SugauchiMasashi Mizokami
Mar 24, 2005·The Journal of General Virology·Zhanhui WangJinlin Hou
May 18, 2005·The Journal of Infectious Diseases·Henry L Y ChanJoseph J Y Sung
Sep 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·D Andrew MerriwetherJonathan S Friedlaender
Oct 15, 2005·Science·Jean-Jacques Jaeger, Laurent Marivaux
Nov 25, 2005·Journal of Virology·Peter Simmonds, Sofie Midgley

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