Jan 1, 1989

Origins and pathways of cerebrovascular nerves storing substance P and calcitonin gene-related peptide in rat

Neuroscience
N SuzukiC Owman

Abstract

Origins and pathways of cerebrovascular substance P- and calcitonin gene-related peptide-positive nerves in rat were studied by immunohistochemistry combined with denervation experiments and retrograde axonal tracer technique. The two peptides have been found to coexist in one and the same neuron. After sectioning of the nasociliary nerve bilaterally the substance P/calcitonin gene-related peptide fibers in the rostral half of the circle of Willis and its branches were eliminated, whereas the number decreased in the caudal half of the circle of Willis and rostral two thirds of the basilar artery. Substance P/calcitonin gene-related peptide fibers in the internal carotid arteries, the caudal third of the basilar artery and the vertebral arteries were not affected by the nerve section. After application of the retrograde axonal tracer True Blue onto the proximal segment of the middle cerebral artery the dye accumulated in several Substance P/calcitonin gene-related peptide-containing cells in the ophthalmic division of the ipsilateral trigeminal ganglion and in a few cells in the maxillary trigeminal division and in the internal carotid miniganglion. No other cranial ganglia accumulating the dye contained any substance P/calciton...Continue Reading

Mentioned in this Paper

August Rats
Immunocytochemistry
Gastroschisis
Trigeminal Nuclei
True blue dihydrochloride, (E)-isomer
Hypothalamic Substance P
Fluorochromes
Calcitonin Gene-Related Peptide II
Diphenylbenzofuran
Structure of Cerebral Artery

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