PMID: 19928407Jan 1, 2007Paper

Origins of health and disease

Revista de la Facultad de Ciencias Médicas
Eduardo Cuestas

Abstract

To present a new area of knowledge, known as developmental origins of health and disease, covering its concepts, study methods and ethical considerations. A review of the medical literature intended to identify current references related to the subject under discussion. The studies demonstrate associations between aggressions suffered during the initial phases of somatic development and amplified risk of chronic diseases throughout life, such as obesity, diabetes and cardiovascular diseases. A variety of models have been proposed in attempts to better explain these associations, such as the thrifty phenotype, programming and predictive adaptive response theories and the concept of match or mismatch. Mechanisms possibly involved in these processes are: effects of the environment on gene expression, through epigenetic mechanisms; effects of hormonal signals transmitted to the fetus via the placenta or the newborn via lactation. Developmental origins of health and diseases draws together information originating from many different areas of knowledge, proposing new investigative methodologies to elucidate the influence of adverse events that occur during early phases of human development on the pattern of health and disease through...Continue Reading

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