Functionally reversible organ shrinkage in rotifers and its modulation by a human-type aggregate

BioRxiv : the Preprint Server for Biology
Zsolt DatkiZ. Galik-Olah

Abstract

Investigation of human neurodegeneration-related aggregates of beta-amyloid 1-42 (A{beta}42) on bdelloid rotifers is a novel interdisciplinary approach in life sciences. We reapplied an organ size-based in vivo monitoring system, exploring the autocatabolism-related alterations evoked by A{beta}42, in a glucose-supplemented starvation model. The experientially easy-to-follow size reduction of the bilateral reproductive organ (germovitellaria) in fasted rotifers was rescued by A{beta}42, serving as a nutrient source- and peptide sequence-specific attenuator of the organ shrinkage phase and enhancer of the regenerative one including egg reproduction. Recovery of the germovitellaria was significant in comparison with the greatly shrunken form. In contrast to the well-known neurotoxic A{beta}42 (except the bdelloids) with specific regulatory roles, the artificially designed scrambled version (random order of amino acids) was inefficient in autocatabolism attenuation, behaving as negative control. This native A{beta}42-related modulation of the functionally reversible organ shrinkage can be a potential experiential and supramolecular marker of autocatabolism in vivo.

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