Origins of pandemic Vibrio cholerae from environmental gene pools

Nature Microbiology
B Jesse ShapiroSalvador Almagro-Moreno

Abstract

Some microorganisms can transition from an environmental lifestyle to a pathogenic one(1-3). This ecological switch typically occurs through the acquisition of horizontally acquired virulence genes(4,5). However, the genomic features that must be present in a population before the acquisition of virulence genes and emergence of pathogenic clones remain unknown. We hypothesized that virulence adaptive polymorphisms (VAPs) circulate in environmental populations and are required for this transition. We developed a comparative genomic framework for identifying VAPs, using Vibrio cholerae as a model. We then characterized several environmental VAP alleles to show that while some of them reduced the ability of clinical strains to colonize a mammalian host, other alleles conferred efficient host colonization. These results show that VAPs are present in environmental bacterial populations before the emergence of virulent clones. We propose a scenario in which VAPs circulate in the environment and become selected and enriched under certain ecological conditions, and finally a genomic background containing several VAPs acquires virulence factors that allow for its emergence as a pathogenic clone.

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Citations

Jun 22, 2018·The New Phytologist·David A Baltrus, Kelly N Orth
Jan 8, 2018·Microbial Genomics·Inès LevadeB Jesse Shapiro
Mar 28, 2018·Journal of Bacteriology·S Nazmus SakibSalvador Almagro-Moreno
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Jan 9, 2021·Journal of Medical Microbiology·Deepak BalasubramanianSalvador Almagro-Moreno

Related Concepts

Alleles
Environment
Genes
Genome
Vibrio cholerae
Virulence
Horizontal
Gene Polymorphism
Comparative Genomic Analysis
Virulence Factors

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