PMID: 8966230Feb 1, 1996Paper

Origins of radiotherapy and radiobiology: separation of the influence of dose per fraction and overall treatment time on normal tissue damage by Reisner and Miescher in the 1930s

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
H Willers, H P Beck-Bornholdt

Abstract

The effect of fractionation on the response of normal tissues to irradiation was already investigated in the 1930s. Reisner (Reisner, A. Hauterythem und Röntgenstrahlung. Erg. Med. Strahlenforsch, 6: 1-60, 1933) measured the time course of skin erythema on thighs of humans by applying different doses per fraction while keeping constant total dose and overall treatment time. The results showed that acute skin damage was reduced with small doses per fraction. Two years later Miescher (Miescher, G. Tierexperimentelle Untersuchungen über den Einfluss der Fraktionierung auf den Späteffekt. Acta Radiol, 16: 25-38, 1935) published his results on late radiation effects in rabbit skin. He also reported that the main influencing factor for tissue tolerance was dose per fraction. In addition, he found indications that there was no impact of overall treatment time on the development of late reactions. Strandqvist in his famous monograph on the time factor in treatment of skin cancer (Strandqvist, M. Studien über die kumulative Wirkung der Röntgenstrahlen bei Fraktionierung. Erfahrungen aus dem Radiumhemmet an 280 Haut -und Lippenkarzinomen. Acta Radiol. (Suppl.) 55: 1-300, 1944), however, postulated that total dose and overall treatment ti...Continue Reading

References

Apr 1, 1987·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S LaukK R Trott
Jan 1, 1969·Clinical Radiology·F Ellis
Dec 1, 1949·The British Journal of Radiology·L COHEN

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Citations

Aug 24, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J-M CossetF Eschwège
Apr 29, 2006·Acta Oncologica·Silvia Johansson
Mar 6, 1998·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·H WillersH P Beck-Bornholdt
Jun 16, 2021·International Journal of Radiation Biology·Marjan BoermaJacqueline P Williams

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