PMID: 6170028Sep 25, 1981Paper

Origins of spinal noradrenergic pathways demonstrated by retrograde transport of antibody to dopamine-beta-hydroxylase

Neuroscience Letters
K N WestlundJ D Coulter

Abstract

Retrograde transport of antibody to dopamine-beta-hydroxylase (DBH) was used to locate the cells of origin of descending noradrenergic (and possibly adrenergic) pathways to the spinal cord. Following injections of DBH antibody into various spinal cord levels, cell bodies were immunocytochemically localized in brainstem nuclei known to contain noradrenergic neurons. These cell groups included the nucleus locus coeruleus, the nucleus subcoeruleus, the medial and lateral parabrachial nuclei, the Kölliker-Fuse nucleus, and the region dorsal and lateral to the superior olivary nucleus. Caudally, none of the noradrenergic cell groups of the medulla contained retrogradely labeled neurons. These findings indicate that the sources of spinal cord noradrenergic input are derived exclusively from the cells of the pons.

References

May 1, 1973·Journal of Neurochemistry·G F Wooten, J T Coyle
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Citations

Oct 15, 1986·Brain Research·K M JohnstonD van der Kooy
Jun 15, 1991·Journal of the Autonomic Nervous System·V A Maisky, N Z Doroshenko
Jun 19, 1992·Brain Research. Developmental Brain Research·N RajaofetraA Privat
Mar 26, 2013·Journal of Chemical Neuroanatomy·Dusica Bajic, Herbert K Proudfit
Apr 2, 2003·Brain Research. Brain Research Reviews·Craig W Berridge, Barry D Waterhouse
Nov 14, 2000·Journal of Neuroscience Methods·R G Wiley, R H Kline IV
Dec 5, 1998·Brain Research. Developmental Brain Research·M Giménez y RibottaA Privat
Mar 14, 1983·Brain Research·K N WestlundJ D Coulter
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·M G ZieglerC R Lake
Dec 17, 2011·The Journal of Comparative Neurology·Eveline BruinstroopClifford B Saper
Feb 1, 1983·Australian and New Zealand Journal of Medicine·P J Thurlow, I F McKenzie

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