Origins, Technological Development, and Applications of Peptidomics

Methods in Molecular Biology
M Schrader

Abstract

Peptidomics is the comprehensive characterization of peptides from biological sources mainly by HPLC and mass spectrometry. Mass spectrometry allows the detection of a multitude of single peptides in complex mixtures. The term first appeared in full papers in the year 2001, after over 100 years of peptide research with a main focus on one or a few specific peptides. Within the last 15 years, this new field has grown to over 1200 publications. Mass spectrometry techniques, in combination with other analytical methods, were developed for the fast and comprehensive analysis of peptides in proteomics and specifically adjusted to implement peptidomics technologies. Although peptidomics is closely linked to proteomics, there are fundamental differences with conventional bottom-up proteomics. The development of peptidomics is described, including the most important implementations for its technological basis. Different strategies are covered which are applied to several important applications, such as neuropeptidomics and discovery of bioactive peptides or biomarkers. This overview includes links to all other chapters in the book as well as recent developments of separation, mass spectrometric, and data processing technologies. Additi...Continue Reading

Citations

Aug 11, 2019·Nutrients·Jing Zhu, Kelly A Dingess
Feb 14, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xin TongXiulan Su
Dec 5, 2020·International Journal of Molecular Sciences·Galina SmolikovaAndrej Frolov
Oct 23, 2020·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Adriana SimizoAlexandre K Tashima
Feb 23, 2021·Frontiers in Immunology·Erik HartmanArtur Schmidtchen
Jul 17, 2021·Journal of Proteome Research·Rachel E ForemanRichard G Kay
Sep 15, 2021·Expert Review of Proteomics·Rui VitorinoSanjeeva Srivastava

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