Ornamental morphology of ionic liquid functionalized ternary doped N, P, F and N, B, F-reduced graphene oxide and their prevention activities of bacterial biofilm-associated with orthopedic implantation

Materials Science & Engineering. C, Materials for Biological Applications
Balaji MurugesanSundrarajan Mahalingam

Abstract

The multifunctional biological active material design for bone tissue engineering is essential to induce osteoblast cell proliferation and attachment. Adhesion of bacteria on biomaterials to produce biofilms can be major contributors to the pathogenesis of implant material associated infections. This research work focuses on NPF& NBF elemental doping and functionalization of reduced graphene oxide using an imidazolium-based ionic liquid such as BMIM PF6 and BMIM BF4 by hydrothermal method. The resulting tri doped reduced graphene oxide (NPF-rGO and NBF-rGO) composite was further used as a scaffold for bone tissue engineering and anti-biofilm activities. The observation of the effect of NPF-rGO and NBF-rGO on the morphology, adhesion and cell proliferation of HOS cell was investigated. Moreover, the tri doped composite tested its antibiofilm properties against B. subtilis, E. coli, K. pneumoniae, and P. aeruginosa pathogenic bacteria. In-vitro studies clearly show the effectiveness of N, P, B, and F doping promoting the rGO mineralization, biocompatibility, and destruction of bacterial biofilm formation. The result of this study suggests that NPF-rGO and NBF-rGO hybrid material will be a promising scaffold for bone reaeration an...Continue Reading

Citations

Dec 10, 2020·International Journal of Molecular Sciences·Alexandra Virginia Bounegru, Constantin Apetrei
Feb 3, 2021·Colloids and Surfaces. B, Biointerfaces·Guihua CaoJianbin Guo
Mar 2, 2021·International Journal of Biological Macromolecules·Kasirajan KasinathanStephen Rajkumar Inbanathan Savariroyan
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Mayakrishnan ArumugamSundrarajan Mahalingam
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Gopalu KarunakaranSelvakumar Rajendran

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