Ornidazole compared to phenoxymethylpenicillin in the treatment of orofacial infections

The Journal of Antimicrobial Chemotherapy
L von Konow, C E Nord

Abstract

A double blind, randomized study comprising 60 patients was undertaken to compare the efficacy of ornidazole to that of phenoxymethylpenicillin in the treatment of orofacial infections. Thirty patients received ornidazole 500 mg orally every 12 h for seven days and were all cured in less than seven days. Five of the 30 patients receiving penicillin, 800 mg orally every 12 h for seven days, did not respond satisfactorily to the treatment given. In two of these instances, beta-lactamase-producing penicillin-resistant Bacteroides strains were isolated. In the present study, ornidazole was found to be more efficient than penicillin in the treatment of orofacial infections. Anaerobes were isolated from all specimens except four that yielded no growth. Anaerobes only were isolated from 65% of the specimens. Since ornidazole was efficient in all cases when given, it is concluded that anaerobic bacteria are the causal pathogens in most orofacial infections.

Citations

Jan 1, 1990·Journal of Clinical Periodontology·A MombelliH Berthold
Jan 29, 2020·Journal of Maxillofacial and Oral Surgery·Uday Kiran Uppada, Ramen Sinha
Jun 1, 1986·Journal of Clinical Microbiology·S A KinderK S Korman
Feb 1, 1990·The British Journal of Oral & Maxillofacial Surgery·R P HapponenP Ylipaavalniemi

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