PMID: 9548335Apr 21, 1998Paper

Ornithine decarboxylase in developing brain of hydrocephalic rats. Effects of shunt operation

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
M IchikawaJ Handa

Abstract

We examined the changes in ornithine decarboxylase (ODC) immunoreactivity in the hydrocephalic cerebral cortex of HTX rats after decompression by shunt operation. The ODC immunoreactivity reached a very low level after the completion of cortical layer formation, and only faint staining was found on postnatal day (Pd) 11. The ODC immunoreactivity re-appeared after the shunt operation when the operation was done in the early days of life: the ODC immunoreactivity was first found on day 2 after shunting and persisted until day 8 after shunting. However, this was not apparent when the operation was not performed until Pd 14. The re-expression of ODC in hydrocephalic brain after shunting appears to cause resumption of the developmental process by relieving neurons from increased hydrostatic pressure. The dependence of ODC re-expression on the timing of the operation indicates that there may be a period of neocortical decompression that is critical for effective compensatory development, so that when delayed, decompression fails to re-activate the ODC-dependent development.

Citations

Apr 25, 2003·Pharmacology & Toxicology·Brian S NielsenOle Ladefoged

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