Oropharyngeal cancer treatment: the role of transoral surgery

Current Opinion in Otolaryngology & Head and Neck Surgery
Michael L HinniBrittany Howard

Abstract

This article reviews literature pertaining to squamous cell carcinoma (SCC) of the oropharynx and the evolution of transoral surgical (TOS) techniques for its management. Oncologists are recognizing a changing pattern in the cause of oropharyngeal cancer, namely the increasing incidence of HPV-associated tumors. An effort is underway to reduce the morbidity of treatment without jeopardizing survival. This is a timely discussion for reassessment of current standards of care and opening dialogue on treatment de-escalation. Transoral approaches including transoral laser microsurgery (TLM) and transoral robotic surgery (TORS) have revolutionized the surgical approach to SCC. The incidence of HPV-related oropharyngeal SCC is increasing at epidemic rates. Although there are no studies comparing nonsurgical treatment to TOS in a randomized controlled fashion, there is an abundance of retrospective and prospective reports of TORS and TLM. Both early and advanced-stage oropharyngeal tumors can be managed successfully with surgery, with or without adjuvant therapy. Although there are no hard scientific differences in oncologic outcomes between primary chemoradiation protocols and primary TOS-based approaches, retrospective comparisons su...Continue Reading

References

Dec 1, 1972·The Annals of Otology, Rhinology, and Laryngology·M S Strong, G J Jako
Sep 28, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mitchell MachtayUNKNOWN Penn Cancer Center Clinical Trials Group
Dec 1, 1960·The Annals of Otology, Rhinology, and Laryngology·A N SCALCOH G TABB
Dec 6, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fabrice DenisGilles Calais
Dec 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan G UrbaDavid E Schuller
Aug 4, 2006·The Laryngoscope·Bert W O'MalleyNeil G Hockstein
Dec 13, 2006·American Journal of Otolaryngology·Nam P NguyenSabah Sallah
Sep 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony J CmelakArlene A Forastiere
May 14, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francis P WordenThomas E Carey
Jun 6, 2008·American Journal of Clinical Oncology·Kathryn M GrevenRalph B D'Agostino
Sep 23, 2009·Archives of Otolaryngology--head & Neck Surgery·Douglas B ChepehaGregory T Wolf
Oct 7, 2009·The Laryngoscope·Peter T DziegielewskiHadi Seikaly
Dec 3, 2009·Head & Neck·Mark E ZafereoMatthew M Hanasono
Dec 23, 2009·Archives of Otolaryngology--head & Neck Surgery·David G GrantJohn D Casler
Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
Aug 11, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Danny RischinGrant A McArthur
Feb 15, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M R PosnerK J Cullen
Feb 22, 2012·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Eric J MooreJared C Inman
Feb 22, 2012·Archives of Otolaryngology--head & Neck Surgery·Kathryn M Van AbelKerry D Olsen
Apr 17, 2012·Acta otorrinolaringológica española·Juan Pablo Díaz-MolinaRamón Alonso
Aug 29, 2012·The Laryngoscope·Bruce H Haughey, Parul Sinha
Nov 28, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arlene A ForastiereJay S Cooper
Feb 6, 2013·The Laryngoscope·Michael L HinniJoseph M Hoxworth
May 7, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·C E WilliamsT M Jones
Oct 12, 2013·JAMA Otolaryngology-- Head & Neck Surgery·Taylor R PolleiLogan C Walter

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Citations

Oct 1, 2015·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Jonathan C MelongS Mark Taylor
Jul 19, 2015·Current Treatment Options in Oncology·Yan Monnier, Christian Simon
Oct 5, 2018·The Laryngoscope·Giancarlo TirelliMarco Piovesana
Dec 7, 2018·The Journal of Craniofacial Surgery·Rosa M MirapeixDavid Virós Porcuna
May 28, 2019·The Annals of Otology, Rhinology, and Laryngology·Brent A ChangMichael L Hinni
Jun 15, 2017·International Journal of Cancer. Journal International Du Cancer·Paolo Boscolo-Rizzo, Andreas Dietz
Feb 23, 2020·Frontiers in Oncology·Erika CrosettiGiovanni Succo
May 31, 2017·Cancers of the Head & Neck·David W SchoppyF Christopher Holsinger
Feb 15, 2017·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Natasha CohenMax Chernesky
Feb 7, 2021·Journal of Robotic Surgery·Velda Ling-Yu ChowRaymond King-Yin Tsang
Mar 24, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ryan S JacksonJoseph Zenga
Jun 1, 2021·The Annals of Otology, Rhinology, and Laryngology·Joshua D WaltonenChristopher A Sullivan

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Methods Mentioned

BETA
dissection

Software Mentioned

TORS

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