PMID: 3383968Apr 1, 1988Paper

Orosomucoid:prealbumin ratio--a marker of the host-tumor relationship in head and neck cancer

European Journal of Cancer & Clinical Oncology
C CaldaniF Demard

Abstract

The OPR was studied in 203 patients with squamous cell carcinoma of the head and neck at the time of diagnosis, before any specific treatment. The mean initial OPR value was significantly higher in cancer patients than in 63 healthy controls: 5.29 +/- 3.09 vs. 2.63 +/- 1.07; P less than 0.001. There was no significant difference by anatomic site, but the OPR was significantly lower in stage I-II disease than in stage III-IV: 5.10 +/- 3.85 vs. 3.23 +/- 1.99, P less than 0.001. An initial OPR under or over 6 seems to be an important prognostic factor: at 2 years, 51% of patients with an OPR less than 6 were alive vs. only 24.5% of those with an OPR greater than 6, P less than 0.001. The difference was also noted in patients with stage III-IV disease (mean survival: 16 months vs. 7 months, P less than 0.001) and in 89 of the patients who received chemotherapy (mean survival 16 months vs. 6 months, P less than 0.001) whatever the response to chemotherapy. The OPR index, which explores nutritional and acute phase reactant proteins, seems to reflect the host-tumor relationship. Its initial value is strongly related to prognosis at 2 years.

References

Aug 1, 1979·British Journal of Urology·J R BastableE H Cooper
Feb 1, 1980·Proceedings of the Society for Experimental Biology and Medicine·H MaedaI Yamane

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Citations

Jul 18, 2001·Pathology Oncology Research : POR·M V CroceA Segal-Eiras
Jun 1, 1996·Clinical Biochemistry·J C CharetP Charet
Mar 18, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sébastien SalasFlorence Duffaud
Nov 1, 1991·Journal of Surgical Oncology·S J PerchJ J Brooks
Feb 15, 1991·Cancer·S Y WongP V Best
Aug 17, 2019·International Journal of Molecular Sciences·Yi-Ta HsiehWan-Chun Li

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