Abstract
The purpose of this study was to compare the effects of a conventional nonsteroidal anti-inflammatory drug, diclofenac (Voltaren [Novartis, Barcelona, Spain]), and a specific cyclooxygenase-2 (COX-2) inhibitor, rofecoxib (Vioxx [MSD, Madrid, Spain]), on the inhibition of dental movement induced with a coil-spring orthodontic apparatus in rats. Tooth movement was measured on the lateral cranial teleradiographs of 42 male Wistar rats in 6 experimental groups: (1) 50-g coil spring and 2 rofecoxib injections of 1 mg per kilogram of body weight; (2) similar orthodontic procedure and 2 diclofenac injections of 10 mg per kilogram of body weight; (3) the same orthodontic treatment and 0.9% saline-solution injections; and (4), (5), and (6) 100-g coil appliance and the same pharmacological treatment as 1, 2, and 3, respectively. The difference in tooth movement, measured in the control animals after 10 days of 50 or 100 g of orthodontic force application, was not statistically significant. Reduction in tooth movement in 50-g traction groups reached statistically significant differences; both rofecoxib or diclofenac were effective in inhibiting dental movement. The comparison of the 3 groups treated with 100 g of force also reached statis...Continue Reading
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