Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid

American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics
Irin SirisoontornNoriaki Yoshida

Abstract

The effect of zoledronic acid, a potent and novel bisphosphonate, on tooth movement and orthodontically induced root resorption in osteoporotic animals systemically treated with zoledronic acid as similarly used in postmenopausal patients has not been elucidated. Therefore, this study was undertaken. Fifteen 10-week-old female Wistar rats were divided into 3 groups: ovariectomy, ovariectomy + zoledronic acid, and control. Only the ovariectomy and ovariectomy + zoledronic acid groups underwent ovariectomies. Two weeks after the ovariectomy, zoledronic acid was administered only to the ovariectomy + zoledronic acid group. Four weeks after the ovariectomy, 25-g nickel-titanium closed-coil springs were applied to observe tooth movement and orthodontically induced root resorption. There were significant differences in the amounts of tooth movement and orthodontically induced root resorption between the ovariectomy and the control groups, and also between the ovariectomy and the ovariectomy + zoledronic acid groups. There was no statistically significant difference in tooth movement and orthodontically induced root resorption between the ovariectomy + zoledronic acid and the control groups. Zoledronic acid inhibited significantly mor...Continue Reading

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Citations

Apr 6, 2013·Head & Face Medicine·Elena KriegerHeinrich Wehrbein
Mar 1, 2013·The Angle Orthodontist·Megumi HashimotoNoriaki Yoshida
Oct 31, 2015·Orthodontics & Craniofacial Research·F J Fernández-GonzálezJ A Vega
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Nov 13, 2015·Dental press journal of orthodontics·Felipe José Fernández-GonzálezJosé Antonio Vega
Apr 23, 2019·European Journal of Orthodontics·Vasileios F ZymperdikasMoschos A Papadopoulos
Aug 15, 2019·Clinical Oral Investigations·Theodosia N BartzelaCharlotte Opitz
Feb 2, 2017·Journal of Lasers in Medical Sciences·Eliziane Cossetin VasconcelosAroline Nemetz Bronfman
Feb 2, 2021·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Hasibe Baser Keklikci, Ahmet Yagci
Jul 9, 2020·Orthodontics & Craniofacial Research·Luiza Lassi de Araújo LopesPhillipe Nogueira Barbosa Alencar
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Nov 21, 2020·European Journal of Orthodontics·Yassir A YassirDavid R Bearn
Jun 28, 2020·Archives of Oral Biology·Eduarda R S AmaroSoraia Macari

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