Orthokeratinized odontogenic cysts: a Spanish tertiary care centre study based on HPV DNA detection

Head & Face Medicine
Beatriz Vera-SireraFrancisco Vera-Sempere

Abstract

The role of human papillomavirus (HPV) in orthokeratinized odontogenic cysts (OOCs) has rarely been studied. The objective is to describe the clinicopathological findings in a series of OOCs from a Spanish population that were investigated in relation to the possible presence of HPV. A clinicopathological retrospective analysis followed by a molecular analysis of 28 high- and low-risk HPV genotypes was performed in OOC samples of patients seen during the last 15-years in a Spanish tertiary care center. Of 115 odontogenic cysts with keratinization, 16 cases of OOCs were confirmed and evaluated. OOCs occurred predominantly in the mandible of males (mean age 36.06 ± 13.16 years). Swelling of the jaw followed by pain were the most common clinical symptoms, and 56.5% of the OOC cases were associated with an unerupted tooth. After a mean post-cystectomy follow-up of 3.8 years, only one recurrent case was observed, resulting in a verrucous cystic lesion that was considered premalignant after immunohistological examination. DNA extraction was successful from 14 of the 16 OOC cases. None of the primary OCCs or the single recurrent OOC were positive for HPV in the molecular analysis. OOCs show a very limited potential for recurrence. Our...Continue Reading

References

Jan 1, 1992·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·T E CrowleyJ C Gunsolley
Mar 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M CoxC Scully
Feb 1, 1987·International Journal of Oral and Maxillofacial Surgery·C H Siar, K H Ng
May 1, 1972·Cancer·R M Browne, N G Gough
Jun 1, 1981·Oral Surgery, Oral Medicine, and Oral Pathology·J M Wright
May 1, 1996·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·H YoshidaH Yusa
Sep 11, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Michael J AldredMervyn Shear
Nov 9, 2002·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Dror AllonShlomo Calderon
Dec 5, 2002·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Mario James A da SilvaVera Cavalcanti De Araújo
Feb 2, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Risa ChaisuparatNikolaos G Nikitakis
Nov 11, 2010·Dento Maxillo Facial Radiology·D S Macdonald-Jankowski
Jun 22, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Lipa BodnerIsaac van der Waal
Jun 7, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Darren P Cox
Jun 12, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marta del PinoRenske D M Steenbergen
Sep 17, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Felipe Paiva FonsecaOslei Paes de Almeida
Feb 26, 2014·Journal of Endodontics·João Paulo Silva ServatoAdriano Mota Loyola
Apr 17, 2014·Head and Neck Pathology·Yi-Shing Lisa ChengTom Teenier
Jun 9, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Manar SammanPamela Rabbitts
Oct 21, 2014·Journal of Oral and Maxillofacial Pathology : JOMFP·Rahul Devidas PimpalkarMandakini S Mandale
Dec 3, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Prokopios P ArgyrisIoannis G Koutlas
Mar 31, 2015·Virchows Archiv : an International Journal of Pathology·Franziska HauckGerald Niedobitek
Oct 22, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Kalpesh LallaShabnum Meer

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