Orthostatic Changes in Blood Pressure and Mortality in the Elderly: The Pro.V.A Study

American Journal of Hypertension
Nicola VeroneseGiuseppe Sergi

Abstract

An extensive, albeit contrasting literature has suggested a possible role for orthostatic hypotension as a risk factor for cardiovascular (CVD) and non-CVD mortality, while no data are available for orthostatic hypertension. We investigated whether orthostatic changes in blood pressure (BP) were associated with any increased risk of all-cause, CVD or non-CVD mortality in a group of elderly people. Two thousand seven hundred and eighty six community-dwelling older participants were followed for 4.4 years. Participants were grouped according to whether they had a drop ≤20 mm Hg in systolic, or ≤10 mm Hg in diastolic BP (orthostatic hypotension), an increase in mean orthostatic systolic BP ≥20 (orthostatic hypertension), or normal changes within 3 minutes of orthostatism. During follow-up, 640 subjects died, 208 of them for CVD-related reasons. Adjusted Cox's regression analysis revealed that, compared with normal changes, orthostatic hypertension was associated with higher all-cause (HR = 1.23; 95% CI: 1.02-1.39) and CVD-related mortality (HR = 1.41; 95% CI: 1.08-1.74), while orthostatic hypotension was only associated with a higher non-CVD mortality (HR = 1.19; 95% CI: 1.01-1.60). Orthostatic hypertension emerged as a predictor ...Continue Reading

References

Jan 1, 1970·The Gerontologist·S KatzR C Grotz
Jul 1, 1983·Archives of General Psychiatry·M F FolsteinJ E Helzer
Jan 1, 1982·Journal of Psychiatric Research·J A YesavageV O Leirer
Nov 7, 2002·Archives of Internal Medicine·Avraham WeissJoseph Grinblat
May 7, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuo EguchiKazuyuki Shimada
Oct 2, 2007·The American Journal of Medicine·Vishal Gupta, Lewis A Lipsitz
Apr 19, 2008·Lancet Neurology·Phillip A Low, Wolfgang Singer
Sep 18, 2008·Journal of the American Geriatrics Society·Germaine C VerwoertJacqueline C M Witteman
May 12, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazuomi Kario
Jul 24, 2010·American Journal of Hypertension·Artur FedorowskiOlle Melander
Sep 4, 2010·American Journal of Hypertension·Luke J Benvenuto, Lawrence R Krakoff
Jan 5, 2011·Hypertension·David Robertson
Jan 5, 2011·Hypertension·Hiroshi YatsuyaUNKNOWN ARIC Study Investigators
Sep 26, 2013·American Journal of Hypertension·Edoardo CasigliaPaolo Palatini
Nov 6, 2013·Nature Reviews. Nephrology·Kazuomi Kario
May 13, 2014·American Journal of Hypertension·Shih-Hsien SungChen-Huan Chen

❮ Previous
Next ❯

Citations

Feb 18, 2016·Heart Failure Reviews·Oleg GorelikNatan Cohen
Oct 21, 2015·Aging Clinical and Experimental Research·Aline GuérinMarc Paccalin
Jul 9, 2016·Internal Medicine Journal·Peter Chisholm, Mahesan Anpalahan
Jul 28, 2016·Journal of Hypertension·Michael BursztynJochanan Stessman
Mar 7, 2017·Blood Pressure Monitoring·Sonsoles M Velilla-ZancadaLuis A Vara-Gonzalez
Mar 17, 2018·American Journal of Hypertension·Davide Agnoletti
May 8, 2018·Journal of the American Heart Association·Stephen P JuraschekElizabeth Selvin
Nov 26, 2015·Hypertension·Davide AgnolettiUNKNOWN PARTAGE study Investigators*
Nov 10, 2018·Current Medical Research and Opinion·Irma TzurOleg Gorelik
Apr 26, 2019·Geriatrics & Gerontology International·Ayumi TobaKazumasa Harada
Mar 31, 2016·Journal of Hypertension·Francesca OmettoNicola Veronese
Sep 15, 2020·Postgraduate Medicine·Xinran LiXiaoping Chen
Aug 14, 2019·Nutrients·Joseph C Watso, William B Farquhar
Jan 28, 2020·Hypertension·Stephen P JuraschekUNKNOWN SPRINT Research Group
Aug 5, 2020·Journal of Cardiovascular Translational Research·Anzhela SolovevaMarat Fudim
Apr 1, 2016·Journal of Hypertension·Laura C HartogKornelis J J van Hateren
May 13, 2017·BMC Neurology·Italo BiaggioniHoracio Kaufmann
Jan 17, 2019·Journal of Human Hypertension·Elias SanidasVasilios Papademetriou
Feb 26, 2019·Journal of Human Hypertension·William J KostisBarry R Davis
Apr 1, 2020·Hypertension·Jens JordanArtur Fedorowski
Jul 14, 2020·Journal of Clinical Neurology·Jung Bin KimByung Jo Kim
Feb 8, 2019·La Presse médicale·Emmanuelle MagnyCarmelo Lafuente-Lafuente

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.