Orthotopic bone formation by implantation of apatite-coated poly(lactide-co-glycolide)/hydroxyapatite composite particulates and bone morphogenetic protein-2

Journal of Biomedical Materials Research. Part a
Sang-Soo KimByung-Soo Kim

Abstract

Bone morphogenetic proteins (BMPs) are the most potent osteoinductive growth factors. However, a delivery system is essential to take advantage of the osteoinductive effect of BMPs. In the present study, we tested the suitability of apatite-coated poly(D,L-lactide-co-glycolide)/nanohydroxyapatite (PLGA/HA) particulates as carriers for the controlled release of BMP-2. The release of BMP-2 from apatite-coated PLGA/HA particulates was sustained for at least 4 weeks in vitro. A delivery system of apatite-coated PLGA/HA particulates suspended in fibrin gel further slowed the BMP-2 release rate. In vivo implantation of either Fibrin gel + BMP-2 or Fibrin gel + apatite-coated PLGA/HA particulates showed enhanced new bone formation in critical-sized calvarial defects of rats 8 weeks after implantation, compared to implantation of fibrin gel only. Importantly, new bone formation was much higher in the defects treated with BMP-2 delivery using apatite-coated PLGA/HA particulates in fibrin gel (Fibrin gel + PLGA/HA + BMP-2 group) than in the defects treated either with apatite-coated PLGA/HA particulates in fibrin gel (Fibrin gel + BMP-2 group) or with BMP-2 delivery using fibrin gel alone (Fibrin gel + BMP-2 group). BMP-2 and osteoinduct...Continue Reading

References

Jan 1, 1990·Methods in Enzymology·M J Gorbunoff
Jan 1, 1973·Methods in Enzymology·G Bernardi
Dec 9, 1993·Clinical Materials·A G Coombes, M C Meikle
Jan 25, 2000·Journal of Biomedical Materials Research·W L MurphyD J Mooney
Oct 31, 2000·Biomaterials·K J BurgJ F Kellam
Feb 22, 2002·Journal of Biomedical Materials Research·Jon A Rowley, David J Mooney
Apr 18, 2003·Biomaterials·Naoto Saito, Kunio Takaoka
Dec 9, 2003·Journal of Biomedical Materials Research. Part a·David LickorishC Rolfe Howlett
Mar 17, 2004·Biomaterials·T MatsumotoJ Takahashi
Sep 16, 2004·Journal of Biomedical Materials Research. Part a·S J KalitaA Bandyopadhyay
Sep 18, 2004·Journal of Biomedical Materials Research. Part a·Michael J MooreMichael J Yaszemski
Oct 7, 2004·Macromolecular Bioscience·Ruiyun Zhang, Peter X Ma
Jun 29, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tse-Ying LiuSz-Chian Liou
Oct 22, 2005·Orthodontics & Craniofacial Research·O Arosarena, W Collins
Nov 30, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yutaka MizushimaAkinori Ueno
Oct 31, 2006·Journal of Biomedical Materials Research. Part a·Sang-Soo KimByung-Soo Kim

❮ Previous
Next ❯

Citations

Aug 14, 2012·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhichao TianJun Xiao
Mar 6, 2010·Anatomical Science International·Priscilla Maria Fernandes AbdalaJoão Paulo Mardegan Issa
May 3, 2011·Tissue Engineering. Part a·Hee Seok YangByung-Soo Kim
Apr 9, 2013·Tissue Engineering. Part a·Hillary E DavisJ Kent Leach
Jul 8, 2014·International Journal of Molecular Sciences·Bill G X ZhangPeter F M Choong
Apr 20, 2012·Advanced Drug Delivery Reviews·Kevin W-H LoCato T Laurencin
Oct 22, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tessa LuhmannLorenz Meinel
Jul 9, 2011·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Frederik Zefanya NotodihardjoKenji Kusumoto
Jul 22, 2008·Biomaterials·Thanaphum OsathanonCecilia M Giachelli
Sep 29, 2011·Journal of Biomedical Materials Research. Part a·Jun-Sik SonKyu-Bok Lee
Feb 15, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Dan LiChangyou Gao
Jul 18, 2009·Journal of Biomedical Materials Research. Part a·Jin Muk KangByung-Soo Kim
Feb 4, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Nicole Y C YuAndrew J Ruys
Sep 12, 2012·Environmental Toxicology and Pharmacology·Khaled RadadWolf-Dieter Rausch
Jan 13, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·Samit K NandiBiman B Mandal
Dec 3, 2010·Neurosurgical Focus·Caroline SzpalskiStephen M Warren
Apr 25, 2012·Advanced Materials·Stephen C Balmert, Steven R Little
Dec 2, 2017·Drug Delivery and Translational Research·Mathieu MaisaniOlivier Chassande
Jan 6, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Pingsheng LiuJie Song
Feb 10, 2016·Tissue Engineering. Part B, Reviews·Aaron W JamesChia Soo
Nov 12, 2021·Expert Opinion on Drug Delivery·Long HuaYihe Hu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.