Orthotopic liver transplantation changes the course of gastric antral vascular ectasia: a case series from a transplant center

European Journal of Gastroenterology & Hepatology
Chaitanya AllamneniShajan Peter

Abstract

Gastric antral vascular ectasia (GAVE) is an important cause of upper gastrointestinal bleeding and anemia in patients with cirrhosis. The aim of our study was to evaluate the effect of orthotopic liver transplantation (OLT) on GAVE and associated anemia. We performed a chart review and identified all cirrhotic patients with GAVE who underwent OLT at the University Of Alabama at Birmingham between 2005 and 2013. Population's demographics, etiology of cirrhosis, comorbidities, presentation and treatment modalities of GAVE, endoscopic and histopathologic reports, hemoglobin values before and after transplant, and immunosuppressive regimens were collected. Twelve patients were identified, mean age 52.4±4.4 years; seven were men (58.3%); 11 (91.7%) were White; and 6 of 12 patients had biopsy-proven GAVE. The most common etiology of cirrhosis in the cohort was chronic hepatitis C and obesity was the most common chronic condition in 50 and 83.3%, respectively. Anemia resolution was observed in 9/12 (75%) patients who underwent OLT with an increase in hemoglobin from 8.1±2.4 (5.7-13.1) before transplant to 12.0±1.4 (10-15) after transplant (P<0.0001). Esophagogastroduodenoscopy after transplant was performed in all 12 (100%) patients....Continue Reading

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Citations

Jan 10, 2019·Scandinavian Journal of Gastroenterology·Michał ŻorniakMarek Hartleb
Jan 30, 2018·World Journal of Gastrointestinal Endoscopy·Tasnia MatinShajan Peter
Jul 3, 2018·Current Gastroenterology Reports·Elliot SmithStephen Caldwell
Dec 15, 2020·World Journal of Hepatology·Saad Emhmed AliAnna Christina Dela Cruz
Apr 20, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·William ShanahanMasood Iqbal

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