Abstract
Veno-occlusive disease of the liver is a serious and often life-threatening complication after bone marrow transplantation. Although risk factors for the development of veno-occlusive disease have been postulated, there is no precise method for accurately identifying those patients who are at risk and for whom early intervention and treatment would have maximum potential benefit. Liver transplantation has been advocated as a treatment for veno-occlusive disease in selected patients. In this report, we describe a patient who underwent liver transplantation for life-threatening veno-occlusive disease after autologous bone marrow transplantation for acute lymphoblastic leukemia. Liver engraftment was achieved, but the patient developed Pneumocystis pneumonia, which failed to respond to pentamidine. The patient died 6 months after liver transplantation. While acknowledging the limited experience of orthotropic liver transplantation in this patient population, we suggest its consideration as a feasible, potentially beneficial treatment option in patients with severe veno-occlusive disease after bone marrow transplantation.
References
Oct 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J A McDonaldG W McCaughan
Mar 1, 1990·British Journal of Haematology·E GluckmanL Drouet
Apr 1, 1990·Transplantation·S D NimerR W Busuttil
Apr 1, 1990·Transplantation·G F CooneyN C Cavarocchi
Dec 1, 1987·Transplantation·R J JonesR Saral
Jun 1, 1985·Transplantation·G B McDonaldE D Thomas
Oct 27, 1994·The New England Journal of Medicine·UNKNOWN U.S. Multicenter FK506 Liver Study Group
Feb 27, 1996·Transplantation·N BuninS Dunn
Citations
Sep 24, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Il-Deok KimKoichi Tanaka
Mar 18, 2003·Transplantation·Yuichi NakazawaSeiji Kawasaki
Feb 10, 2009·Transplantation·Akinobu TaketomiYoshihiko Maehara
May 25, 2006·International Journal of Hematology·Christian KoeneckeJuergen Klempnauer
Jul 30, 2011·World Journal of Gastroenterology : WJG·Timothée NoterdaemeOlivier Detry
Nov 26, 2014·Transplantation Proceedings·I D KostakisG Kouraklis
Mar 29, 2001·Public Health Nutrition·F Stickel, H K Seitz
Dec 30, 1998·Leukemia & Lymphoma·P Richardson, S I Bearman
Oct 9, 2007·Journal of Pharmaceutical Sciences·Rajesh SinghJames W Lillard
Oct 22, 2008·Transplantation Proceedings·C-H LeeF-R Chuang
Apr 24, 2008·Clinical Transplantation·Fernando E MembrenoCharles F LeMaistre
Nov 19, 2009·Clinical Transplantation·Amer BeitinjanehNavneet S Majhail
Feb 14, 2006·Seminars in Oncology·Justin FloydMichael C Perry
Apr 15, 2003·Bone Marrow Transplantation·K Y Chiang, H M Lazarus
May 9, 2000·Bone Marrow Transplantation·D AzoulayH Bismuth
Aug 8, 2018·Bone Marrow Transplantation·Jens G BrockmannMahmoud Aljurf
Aug 9, 2003·Expert Opinion on Drug Safety·Bradley SachsMichael C Perry
Jul 5, 2013·The American Journal of Case Reports·Hisamitsu MiyaakiKazuhiko Nakao
May 7, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Young-Dong YuYong Park