OSCAR-collagen signaling in monocytes plays a proinflammatory role and may contribute to the pathogenesis of rheumatoid arthritis

European Journal of Immunology
Heidi S SchultzSvetlana Panina

Abstract

Osteoclast-associated receptor (OSCAR) is an activating receptor expressed by human myeloid cells. Collagen type I (ColI) and collagen type II (ColII) serve as ligands for OSCAR. OSCAR-collagen interaction stimulates RANK-dependent osteoclastogenesis. We have recently reported that OSCAR promotes functional maturation of monocyte-derived dendritic cells. OSCAR is upregulated on monocytes from rheumatoid arthritis (RA) patients with active disease, and these monocytes show an increased proosteoclastogenic potential. In the current study, we have addressed a functional role for an OSCAR-collagen interaction on monocytes. We show that OSCAR-ColII signaling promoted the survival of monocytes. Moreover, ColII stimulated the release of proinflammatory cytokines by monocytes from healthy donors, which could be completely blocked by an anti-OSCAR monoclonal antibody. Mononuclear cells from the synovial fluid of RA patients plated on ColII secreted TNF-α and IL-8 in an OSCAR-dependent manner. Global RNA profiling showed that components of multiple signaling pathways relevant to RA pathogenesis are regulated at the transcriptional level by OSCAR in monocytes. Thus, OSCAR can play a proinflammatory role in monocyte-derived cells and may c...Continue Reading

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Citations

Feb 29, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Liumeng Jian, Guangda Yang
Feb 27, 2020·Cellular and Molecular Life Sciences : CMLS·Henrik J JürgensenDaniel H Madsen
Apr 5, 2020·Clinical and Experimental Pharmacology & Physiology·Dong WangShengzhi Xie
Mar 7, 2019·Immune Network·Youn-Kwan JungSeungwoo Han
May 31, 2018·Molecular Medicine Reports·Jian XuZhenzhong Gao
Apr 4, 2021·Cells·Jordan HollAndrzej Eljaszewicz

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