PMID: 6965320Jan 10, 1980Paper

Oscillation of [Ca2+]i-linked K+ conductance in bullfrog sympathetic ganglion cell is sensitive to intracellular anions

Nature
K MoritaK Kuba

Abstract

The intracellular free Ca2+ ([Ca2+]i) regulates the K+ conductance (GK) of the many types of cell membrane. The Ca2+ influx during an action potential activates this [Ca2+]i-linked GK in most neurones. In caffeine-treated sympathetic ganglion cells, however, Ca2+ released from an intracellular Ca2+ reservoir site analogous to the sarcoplasmic reticulum (SR) of the muscle (see ref. 12) causes activation of the GK, which results in slow oscillatory hyperpolarisations (caffeine hyperpolarisation, C-hyperpolarisation). Such a release of Ca2+ linked to the GK of the membrane seems important for understanding the role of the intracellular organelles in the control of membrane activities of a neurone. We report here the mechanism of the slow oscillatory hyperpolarisations recorded from the bullfrog sympathetic ganglion cell in Ringer solution. It is found that these hyperpolarisations are generated by a [Ca2+]i-linked GK system and are highly sensitive to anions in an intracellular recording electrode, probably to intracellular anions.

References

Jan 1, 1977·Physiological Reviews·M Endo
Jan 1, 1978·Progress in Neurobiology·K Kuba, K Koketsu
Jan 1, 1978·Annual Review of Biophysics and Bioengineering·R W Meech
Jun 1, 1972·Comparative Biochemistry and Physiology. A, Comparative Physiology·R W Meech
Mar 1, 1974·The Journal of Physiology·R W Meech
Sep 1, 1972·The Journal of Physiology·K Krnjević, A Lisiewicz
Dec 1, 1958·Biochimica Et Biophysica Acta·G GARDOS

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Citations

Oct 1, 1987·Pflügers Archiv : European journal of physiology·K Tanaka, K Kuba
Nov 1, 1983·Pflügers Archiv : European journal of physiology·K KubaM Nohmi
Jul 15, 1982·Brain Research·K KoketsuM Miyagawa
Jan 20, 1987·Brain Research·L S Satin, P R Adams
Jul 1, 1983·Journal of the Autonomic Nervous System·T Suzuki, K Kusano
Sep 1, 1988·Journal of the Autonomic Nervous System·T NishimuraT Akasu
Jan 25, 2003·Cell Calcium·A Verkhratsky
Nov 9, 2000·The European Journal of Neuroscience·N SzilágyiJ Kardos
Jul 28, 2010·Journal of Theoretical Biology·Assieh SaadatpourRéka Albert
Feb 3, 2004·Journal of Cellular and Molecular Medicine·A Verkhratsky, E C Toescu
Sep 6, 2006·Biophysical Chemistry·Chun-Lian ZhuXuan Zhan
Dec 30, 2011·Computers in Biology and Medicine·Teodor BuchnerPaweł Kuklik
Dec 21, 1981·Journal of Theoretical Biology·K Kuba, S Takeshita
Nov 18, 1998·Journal of Neurophysiology·G ErdemliK Krnjević
Mar 5, 2002·European Journal of Biochemistry·Stefan SchusterThomas Höfer

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