PMID: 6969315Sep 30, 1980Paper

Oscillation of the electric potential of frog skin under the effect of Li+: experimental approach

The Journal of Membrane Biology
J P LassallesM Thellier

Abstract

When a frog skin is used to separate two compartments, and lithium is added to the external medium, transmembrane electric potential oscillations frequently occur. When no external current is imposed, sustained oscillations, with a period of about 10 min, are maintained for several hours. An oscillation of the Na+ influx accompanies the electric oscillation, though the two oscillations are out of phase to a greater or less extent. Theophyllin promotes a significant decrease in the mean electric potential of the skin, but it does not affect very much the characteristics of the oscillation. Important factors influencing the oscillation are temperature, permeability of the external membrane to lithium, and potassium concentration in the internal medium. No correlation can be detected between oscillation characteristics and skin area. This suggests that the oscillation is of a local nature, possibly originating at the cellular level. Occurrence of macroscopic oscillations implies coupling between local oscillators. Coupling between two epithelia has been studied under diverse conditions. The coupling is of an electrical nature: by varying the value of the coupling resistance, it is possible to control synchronization of the oscilla...Continue Reading

References

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Citations

Jan 1, 1990·Pflügers Archiv : European journal of physiology·C P Hansen, O Frederiksen
May 1, 1986·Pflügers Archiv : European journal of physiology·C P HansenO Frederiksen
Jan 1, 1983·The Journal of Membrane Biology·J AboulafiaF Lacaz-Vieira
Dec 17, 2002·Comptes rendus biologies·Christophe LetellierMichel Thellier
May 21, 2003·Comptes rendus biologies·Michel ThellierCamille Ripoll
Feb 1, 1986·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·J F Ryley

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