Oscillatory calcium responses mediated by P2Y2 purinergic receptors in terminal Schwann cells of longitudinal lanceolate endings isolated from rat vibrissae

The Journal of Comparative Neurology
H Takahashi-Iwanaga, Yoshiaki Habara

Abstract

The longitudinal lanceolate endings are mechanoreceptors that detect hair movement. We have previously shown that terminal Schwann cells, glial elements of the sensory devices, respond to an application of the sensory modulator adenosine 5'-triphosphate (ATP) by an elevation in the intracellular Ca2+ concentration ([Ca2+]i), suggesting a regulatory role for these cells in the cutaneous sensation. To define the spatiotemporal dynamics of the cell signaling and the pharmacological properties of the receptors responsible, arrays of the lanceolates were enzymatically isolated from the rat vibrissal follicle and subjected to [Ca2+]i image recording by time-lapse confocal microscopy during bath application of ATP analogues. The terminal Schwann cells formed extensive networks, connecting with one another by their lamellar processes associated with lanceolate axon endings. Stimulation of the cells with 100 microM ATP evoked [Ca2+]i waves propagating along the cell processes. In each Schwann lamella, the initial wave evoked by a given trial of the stimulant arose from a specific locus within the cell process, whereas subsequent waves were sometimes observed to travel from its proximal portion. This implies a subcellular compartmentaliz...Continue Reading

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Citations

Mar 3, 2012·Histochemistry and Cell Biology·Yasufumi Soda, Yoshio Yamamoto
Dec 11, 2007·The Journal of Comparative Neurology·Toshiyuki Kaidoh, Takao Inoué
Jul 11, 2008·The Journal of Comparative Neurology·Hiromi Takahashi-IwanagaKishio Furuya
Dec 17, 2011·The Journal of Comparative Neurology·Hiromi Takahashi-Iwanaga, Toshihiko Iwanaga
Jan 14, 2005·Journal of Neurophysiology·Y Q Lin, M R Bennett
Nov 16, 2020·The Journal of Comparative Neurology·Masato HirakawaTomoyuki Saino

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