Oscillatory control of Delta-like1 in somitogenesis and neurogenesis: A unified model for different oscillatory dynamics

Seminars in Cell & Developmental Biology
Hiromi Shimojo, Ryoichiro Kageyama

Abstract

During somite segmentation, mRNA expression of the mouse Notch ligand Delta-like1 (Dll1) oscillates synchronously in the presomitic mesoderm (PSM). However, the dynamics of Dll1 protein expression were rather controversial, and their functional significance was not known. Recent live-imaging analysis showed that Dll1 protein expression also oscillates synchronously in the PSM. Interestingly, accelerated or delayed Dll1 expression by shortening or elongating the Dll1 gene, respectively, dampens or quenches Dll1 oscillation at intermediate levels, a phenomenon known as "amplitude/oscillation death" of coupled oscillators in mathematical modeling. Under this condition, oscillation of the Notch effector Hes7 is also dampened, leading to severe fusion of somites and their derivatives, such as vertebrae and ribs. Thus, the appropriate timing of Dll1 expression is critical for its oscillatory expression, pointing to the functional significance of Dll1-mediated oscillatory cell-cell interactions in the segmentation clock. In neural stem cells, Dll1 expression is also oscillatory, but non-synchronous, and when Dll1 oscillation is dampened, oscillation of another Notch effector, Hes1, is also dampened, leading to defects of neural develo...Continue Reading

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Citations

Feb 21, 2016·Seminars in Cell & Developmental Biology·Caroline J Sheeba
Nov 27, 2016·Arthropod Structure & Development·Bo-Kai Liao, Andrew C Oates
Sep 27, 2018·Journal of Cellular and Molecular Medicine·Gen ZhengJohn W Wiley
Dec 31, 2019·Development, Growth & Differentiation·Katsuto Hozumi
May 20, 2018·Physical Review. E·David J JörgFrank Jülicher
Jul 25, 2019·Physical Review. E·Gabriela PetrungaroLuis G Morelli
Sep 20, 2018·Proceedings of the National Academy of Sciences of the United States of America·Yu-Er WuSato Honma
Aug 2, 2020·Scientific Reports·Thomas G MinchingtonNancy Papalopulu
Aug 26, 2018·Journal of Cellular Biochemistry·Joanna B Tyrovola
Sep 19, 2018·Neuroscience Research·Ryoichiro KageyamaToshiyuki Ohtsuka
May 26, 2021·Molecular Systems Biology·Veronica BigaNancy Papalopulu
Nov 13, 2017·ACS Biomaterials Science & Engineering·Alexander A Spector, Warren L Grayson
May 5, 2018·ACS Synthetic Biology·Marco SantorelliDiego di Bernardo

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