Oscillatory lower body negative pressure impairs task related functional hyperemia in healthy volunteers

American Journal of Physiology. Heart and Circulatory Physiology
Julian M StewartMarvin S Medow

Abstract

Neurovascular coupling refers to the link between an increase in neural activity in response to a task and an increase in cerebral blood flow denoted "functional hyperemia." Recent work on postural tachycardia syndrome indicated that increased oscillatory cerebral blood flow velocity (CBFv) was associated with reduced functional hyperemia. We hypothesized that a reduction in functional hyperemia could be causally produced in healthy volunteers by using oscillations in lower body negative pressure (OLBNP) to force oscillations in CBFv. CBFv was measured by transcranial Doppler ultrasound of the left middle cerebral artery. We used passive arm flexion applied during eight periodic 60-s flexion/60-s relaxation epochs to produce 120-s periodic changes in functional hyperemia (at 0.0083 Hz). We used -30 mmHg of OLBNP at 0.03, 0.05, and 0.10 Hz, the range for cerebral autoregulation, and measured spectral power of CBFv at all frequencies. Arm flexion power performed without OLBNP was compared with arm flexion power during OLBNP. OLBNP power performed in isolation was compared with power during OLBNP plus arm flexion. Cerebral flow velocity oscillations at 0.05 Hz reduced and at 0.10 Hz eliminated functional hyperemia, while 0.03 Hz d...Continue Reading

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Citations

May 31, 2017·Physiological Reports·Marvin S MedowJulian M Stewart
Feb 6, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Sana MerchantJulian M Stewart
Feb 20, 2018·Journal of Physiological Anthropology·Erin D Ozturk, Can Ozan Tan

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