PMID: 9187637Jun 1, 1997Paper

Oscillatory potentials and light microscopic changes demonstrate an interaction between zinc and taurine in the developing rat retina

The Journal of Nutrition
K T Gottschall-PassP G Paterson

Abstract

Our objective was to investigate whether zinc interacts with taurine to influence the development of retinal structure and function. Virgin female Sprague-Dawley rats were bred overnight and assigned to one of four treatments in a 2 x 2 factorial design with two levels of zinc (50 micrograms/g through gestation and 50 micrograms/g after parturition; 15 micrograms/g through gestation and 7.5 micrograms/g after parturition) and two levels of taurine (2 or 0 mumol/g). The control diet contained 50 micrograms/g zinc and 2 mumol/g taurine. Guanidinoethyl sulfonate (10 g/L), a taurine transport inhibitor, was added to the drinking water of the rats receiving 0 mumol/g taurine. At postnatal d 23, male pups (n = 10) were weaned onto their respective diets. Pup eyes were examined by biomicroscope and indirect ophthalmoscope at 4 and 7 wk; retinal folds and choroidal atrophy were detected in the pups deficient in zinc and taurine. Analysis of plasma zinc and tibial zinc concentrations revealed a significant interaction in these tissues (P < 0.05). Dark-adapted oscillatory potentials (OP) were recorded at 7.5-8.5 wk. Two-way ANOVA showed a significant interaction between zinc and taurine for OP2 and OP3 amplitudes; marginal zinc deficienc...Continue Reading

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Citations

Dec 20, 2005·Neurochemical Research·S NusettiL Lima
Nov 17, 2004·Neurotoxicity Research·R DawsonM Hu
Aug 29, 2013·Biochemistry. Biokhimii︠a︡·S A Shukolyukov
May 15, 2001·Journal of the American College of Nutrition·B H GrahnZ Zhang
Oct 31, 2003·Journal of the American Veterinary Medical Association·Robert C BackusAndrea J Fascetti

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