Abstract
To assess influenza-related secondary complications and healthcare use and costs in patients prescribed oseltamivir for influenza. This study examined health insurance claims data for patients diagnosed with influenza during five influenza seasons. Patients prescribed oseltamivir were propensity matched with patients not prescribed antiviral therapy. Clinical outcomes were diagnosis with pneumonia, otitis media and hospitalizations, along with in-patient, out-patient and pharmacy use and costs. Each group included 45,751 patients. Patients prescribed oseltamivir had significant reductions in the risks of pneumonia (odds ratio [OR]: 0.89, 95% CI: 0.80, 1.00), otitis media (OR: 0.84, 95% CI: 0.77, 0.91) and hospitalization (OR: 0.71, 95% CI: 0.62, 0.83). The risks of pneumonia and otitis media were also lower in children and adolescents (< or = 17 years) prescribed oseltamivir (OR: 0.74, 95% CI: 0.60, 0.91 and OR: 0.77, 95% CI: 0.69, 0.85, respectively). Total healthcare costs were lower for patients prescribed oseltamivir versus no antiviral therapy (mean US$500 versus 510; p < 0.0001). Patients prescribed oseltamivir had fewer claims per patient for antibiotics (0.37 versus 0.45; p < 0.0001), fewer physician visits (1.72 versus...Continue Reading
References
Sep 27, 1993·Archives of Internal Medicine·A M McBeanJ L Warren
Oct 1, 1993·Journal of Clinical Epidemiology·P S RomanoJ G Jollis
Jun 6, 1998·Occupational Medicine·M KeechP J Ryan
Mar 17, 1999·JAMA : the Journal of the American Medical Association·K M NeuzilM R Griffin
Dec 9, 1995·PharmacoEconomics·P Davey
Dec 9, 1995·PharmacoEconomics·K M Sullivan
Aug 24, 1999·American Journal of Epidemiology·M M Joffe, P R Rosenbaum
Oct 12, 1999·JAMA : the Journal of the American Medical Association·F G HaydenS E Straus
Jan 29, 2000·The New England Journal of Medicine·K M NeuzilM R Griffin
Mar 4, 2000·JAMA : the Journal of the American Medical Association·J J TreanorR G Mills
Jul 6, 2000·The Journal of Antimicrobial Chemotherapy·T Szucs
Oct 4, 2000·JAMA : the Journal of the American Medical Association·C B BridgesK Fukuda
Feb 27, 2001·The Pediatric Infectious Disease Journal·R J WhitleyP Ward
Mar 20, 2001·Archives of Internal Medicine·K L Nichol
Aug 21, 2002·Annals of Internal Medicine·Patrick Y LeeEric D Peterson
Dec 21, 2002·The Journal of Antimicrobial Chemotherapy·F Y AokiUNKNOWN IMPACT Study Group
Jun 7, 2003·BMJ : British Medical Journal·Nicola J CooperKarl G Nicholson
Jul 29, 2003·American Journal of Epidemiology·M Soledad CepedaBrian L Strom
Jul 30, 2003·Archives of Internal Medicine·Laurent KaiserFrederick Hayden
Sep 11, 2003·Annals of Internal Medicine·Michael B RothbergDavid N Rose
Sep 21, 2004·The Journal of Infectious Diseases·Terho HeikkinenTaina Juven
Nov 6, 2004·Respiratory Medicine·Gabrielle CieslaJeffrey Stoddard
Feb 3, 2005·Pharmacy World & Science : PWS·Majbrit Vindt HolmEbba Holme Hansen
Jun 23, 2005·Current Medical Research and Opinion·Beth L NordstromPriscilla Szneke
Jan 31, 2006·Lancet·T JeffersonA Rivetti
Apr 25, 2006·Journal of Clinical Epidemiology·Til StürmerSebastian Schneeweiss
Nov 3, 2006·Pediatrics·Ron KerenSusan E Coffin
Dec 5, 2006·Pediatrics·Krow AmpofoRajendu Srivastava
Dec 14, 2006·Clinical Drug Investigation·Robert BettisMarlene Gyldmark
Mar 16, 2007·Current Medical Research and Opinion·Charles E BarrJohn S Bradley
Apr 26, 2007·Cancer·Elenir B C AvritscherLinda S Elting
Citations
Feb 20, 2009·Journal of General Internal Medicine·Jeffrey A LinderWilliam A Blumentals
Mar 20, 2010·The Journal of Antimicrobial Chemotherapy·Regina Dutkowski
Sep 6, 2011·Emerging Infectious Diseases·Charisma Y AtkinsMartin I Meltzer
Jul 19, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael G Ison
Feb 24, 2015·Archives of public health = Archives belges de santé publique·Ralph CrottMarie-Christine Closon
Mar 29, 2011·Expert Opinion on Pharmacotherapy·Paolo Preziosi
Nov 18, 2015·Influenza and Other Respiratory Viruses·Léon NshimyumukizaDaniel Reinharz
Apr 23, 2014·Journal of Korean Medical Science·Jacqueline K LimYun-Kyung Kim
Feb 12, 2013·Influenza and Other Respiratory Viruses·Charles R BeckUNKNOWN UK Antiviral Effectiveness Review Group
Aug 12, 2009·Cell Host & Microbe·Aimee K ZaasGeoffrey S Ginsburg
Feb 20, 2015·Expert Review of Anti-infective Therapy·Michael G Ison
Apr 8, 2016·Current Medical Research and Opinion·Philip J SpagnuoloLizheng Shi
Oct 27, 2016·Human Vaccines & Immunotherapeutics·Anita J BroganGenevieve Meier
Feb 16, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sudhir VenkatesanJonathan S Nguyen-Van-Tam
Apr 20, 2012·The Cochrane Database of Systematic Reviews·Kay WangAnthony Harnden
Feb 24, 2009·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Sandra E TalbirdBeate Sander
Aug 31, 2010·Paediatric Drugs·Steven M Smith, John G Gums
Feb 28, 2019·Current Medical Research and Opinion·Vanessa TaiebNobuo Hirotsu
Jan 19, 2012·The Pediatric Infectious Disease Journal·Shikha GargLyn Finelli
Jul 18, 2019·The Journal of Infectious Diseases·Sudhir VenkatesanJonathan S Nguyen-Van-Tam
Sep 30, 2020·Journal of Korean Medical Science·Kyeong Hyang ByeonNakyoung Lee
Feb 12, 2021·Journal of Medical Economics·Chris WallickDalia Moawad
Jul 23, 2021·Clinical Drug Investigation·Xiao LiPhilippe Beutels
Mar 16, 2021·Terapevticheskiĭ arkhiv·V TaiebN Hirotsu