PMID: 18403897Apr 12, 2008Paper

Oseltamivir enhances hippocampal network synchronization

Journal of Pharmacological Sciences
Atsushi UsamiYuji Ikegaya

Abstract

Oseltamivir, a widely used anti-influenza drug, inhibits virus neuraminidase. A mammalian homologue of this enzyme is expressed in the brain, yet the effect of oseltamivir on central neurons is largely unknown. Patch-clamp recordings ex vivo revealed that oseltamivir enhanced spike synchronization between hippocampal CA3 pyramidal cells. Time-lapse multineuron calcium imaging revealed that oseltamivir and its active metabolite evoked synchronized population bursts that recruited virtually all neurons in the network. This unique, so-far-unknown, event was attenuated by muscarinic receptor antagonist. Thus, oseltamivir is a useful tool for investigating a new aspect of neural circuit operation.

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Citations

Mar 11, 2009·Human & Experimental Toxicology·Y IzumiT Narahashi
May 4, 2010·Analytical and Bioanalytical Chemistry·Naoya TakahashiYuji Ikegaya
Jan 6, 2009·Biological & Pharmaceutical Bulletin·Shigehiro Namiki, Yuji Ikegaya
Sep 2, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yuji Ikegaya
Apr 25, 2012·Basic & Clinical Pharmacology & Toxicology·Satoko KimuraAkira Haji
May 12, 2009·Journal of Pharmacological Sciences·Mika MizunumaYuji Ikegaya
Mar 11, 2010·Chemistry : a European Journal·Jimei MaXue-Wei Liu
May 8, 2019·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hideki Ono

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