Oseltamivir (Tamiflu) and its potential for use in the event of an influenza pandemic

The Journal of Antimicrobial Chemotherapy
P WardR Dutkowski

Abstract

Recent cross species transmission of avian influenza has highlighted the threat of pandemic influenza. Oseltamivir (Tamiflu) has been shown to be effective in the treatment and prevention of epidemic influenza infection in adults, adolescents and children (> or = 1 year). Although oseltamivir has not been approved for prophylactic use in children, it has been shown to be effective. Oseltamivir is also active against avian influenza virus strains. Evidence suggests that lower doses or shorter durations of treatment/chemoprophylaxis other than those approved may not be effective and may contribute to emergence of viral resistance. Safety data from dose ranging studies show that 5 day courses of 150 mg twice daily for treatment and 6 week courses of 75 mg twice daily for prophylaxis were as well tolerated as the approved dose regimens. The use of oseltamivir in a pandemic is influenced by the goals of the pandemic plan developed by the responsible Government and Health Authority. To optimize use of antiviral medications, processes will be needed to collect, collate and report outcome data from treated patients and/or from use for chemoprophylaxis of pandemic influenza during the first-wave outbreaks. If oseltamivir is included in ...Continue Reading

Citations

Apr 14, 2007·Medical Microbiology and Immunology·Jindrich CinatlHans W Doerr
Aug 17, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R K SaxenaG Rawat
Mar 26, 2013·Antiviral Research·Mélanie SamsonGuy Boivin
Jan 31, 2006·Lancet·T JeffersonA Rivetti
Sep 6, 2011·Prehospital and Disaster Medicine·Karen P PhillipsCarol A Amaratunga
Dec 24, 2005·The New England Journal of Medicine·Menno D de JongJeremy Farrar
Sep 30, 2005·The New England Journal of Medicine·John H BeigelUNKNOWN Writing Committee of the World Health Organization (WHO) Consultation on Human Influenza A/H5
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rupert J RussellJohn J Skehel
Dec 14, 2006·The Journal of Infectious Diseases·Frederick G Hayden, Andrew T Pavia
Apr 22, 2008·The Journal of Infectious Diseases·David A BoltzElena A Govorkova
Jun 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Arnold S Monto
Dec 17, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Frederick Hayden
Jan 13, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Iain StephensonMaria Zambon
Jul 10, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Arnold S Monto
Jan 24, 2007·Biosecurity and Bioterrorism : Biodefense Strategy, Practice, and Science·Thomas V InglesbyD A Henderson
Mar 20, 2010·The Journal of Antimicrobial Chemotherapy·Regina Dutkowski
Mar 20, 2010·The Journal of Antimicrobial Chemotherapy·James R Smith
Aug 30, 2007·Journal of the Royal Society, Interface·N Arinaminpathy, A R McLean
Aug 31, 2006·Antimicrobial Agents and Chemotherapy·Niklas LindegardhNicholas J White
Aug 31, 2006·Antimicrobial Agents and Chemotherapy·M A Rameix-WeltiN Naffakh
Feb 14, 2007·Antimicrobial Agents and Chemotherapy·Elena A GovorkovaRobert G Webster
Jan 7, 2009·Antimicrobial Agents and Chemotherapy·Varough M DeydeLarisa V Gubareva
Feb 28, 2007·Antimicrobial Agents and Chemotherapy·Niklas LindegardhNicholas J White
Apr 13, 2007·Clinical Microbiology Reviews·J S Malik PeirisYi Guan
Apr 12, 2012·Clinical Microbiology Reviews·Swati Kumar, Kelly J Henrickson
Jul 30, 2010·Journal of Clinical Microbiology·Darwin J OperarioKirsten St George
Jul 31, 2009·Journal of Virology·Aeron C HurtIan G Barr
Jun 14, 2008·Infectious Diseases in Obstetrics and Gynecology·Kevin C WorleyRoger E Bawdon
Dec 4, 2009·BMC Medicine·Seyed M MoghadasJianhong Wu
Nov 1, 2008·Virology Journal·Stefan O BrockmannMartin Eichner
Jan 27, 2007·PLoS Medicine·Marc LipsitchBruce R Levin
Mar 20, 2008·PloS One·Seyed M MoghadasJianhong Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.