OSgbm: An Online Consensus Survival Analysis Web Server for Glioblastoma

Frontiers in Genetics
Huan DongXiangqian Guo

Abstract

Glioblastoma (GBM) is the most common malignant tumor of the central nervous system. GBM causes poor clinical outcome and high mortality rate, mainly due to the lack of effective targeted therapy and prognostic biomarkers. Here, we developed a user-friendly Online Survival analysis web server for GlioBlastoMa, abbreviated OSgbm, to assess the prognostic value of candidate genes. Currently, OSgbm contains 684 samples with transcriptome profiles and clinical information from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and Chinese Glioma Genome Atlas (CGGA). The survival analysis results can be graphically presented by Kaplan-Meier (KM) plot with Hazard ratio (HR) and log-rank p value. As demonstration, the prognostic value of 51 previously reported survival associated biomarkers, such as PROM1 (HR = 2.4120, p = 0.0071) and CXCR4 (HR = 1.5578, p < 0.001), were confirmed in OSgbm. In summary, OSgbm allows users to evaluate and develop prognostic biomarkers of GBM. The web server of OSgbm is available at http://bioinfo.henu.edu.cn/GBM/GBMList.jsp.

References

Nov 12, 2003·Journal of Neurosurgery·Kuo-Sheng Hung, Shen-Long Howng
Mar 5, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amy B HeimbergerKenneth Aldape
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
May 21, 2005·International Journal of Cancer. Journal International Du Cancer·Christian Philipp PallaschEckart Meese
Oct 28, 2008·Journal of Neuro-oncology·Katsuyuki ShiraiTakashi Nakano
May 12, 2009·Journal of Neuro-oncology·Charlotte Aaberg-JessenBjarne Winther Kristensen
Apr 30, 2011·Archives of Pathology & Laboratory Medicine·Marina N Nikiforova, Ronald L Hamilton
Aug 29, 2012·Journal of Surgical Oncology·Dakeun LeeSung Tae Kim
Feb 16, 2013·International Journal of Biological Sciences·Xiangli CuiSong Lin
Feb 19, 2013·Journal of Neuro-oncology·Shi-Yong WangChang-Chen Hu
Jun 7, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·O F OlmezO Manavoglu
Oct 12, 2014·Journal of Translational Medicine·Delong MengDaru Lu
May 7, 2015·Acta Neuropathologica·Kenneth AldapeAndreas von Deimling
May 28, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jiaxin ZhaoPeng Liang
Aug 21, 2015·British Journal of Cancer·C MarisI Salmon
Sep 2, 2015·Neuro-oncology·Edjah K NduomAmy B Heimberger
Apr 29, 2016·Diagnostic Pathology·Giedrius SteponaitisPaulina Vaitkienė
Aug 2, 2016·Journal of Korean Medical Science·Ajay ChaurasiaChul-Kee Park
Jan 18, 2017·Journal of Neuro-oncology·Xiaoshud DongTaketoshi Maehara
Jun 15, 2017·International Journal of Cancer. Journal International Du Cancer·Haitao GeJianping Huang
Aug 2, 2017·Cancer Biomarkers : Section a of Disease Markers·Lina DengDan Deng
Aug 9, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kui Luo, Kai Zhuang
Sep 20, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Wenqing ZhangZongpeng Li
Nov 8, 2017·Journal of Experimental & Clinical Cancer Research : CR·Ming-Zhi HanJian Wang
Dec 23, 2017·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Tomohide HayashiSatoshi Kuroda
Feb 2, 2018·Medical Oncology·George S StoyanovAnton B Tonchev

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Datasets Mentioned

BETA
GSE7696
GSE42669

Software Mentioned

Tomcat
CGGAarray
Windows
MySQL
OSgbm
CGGAseq
R package
J2EE

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