Oslo study: treatment of mild hypertension. A five-year controlled drug study

Nephron
A Helgeland, P Leren

Abstract

During 1972-1973, 785 symptom-free men, aged 40-49, with mild hypertension, were randomly assigned to a 5-year controlled drug treatment study, 406 in the treatment group and 379 in the control group. The basic drug was hydrochlorothiazide, in addition methyldopa or propranolol if necessary. The mean observation time was 66 months (range 60-78). At 5 years' follow-up there was no difference in total mortality between treated and controls, nor in cardiovascular mortality. There was a good prevention of cerebrovascular disease (0 vs. 7). Regarding coronary heart disease, however, there was an opposite trend (20 vs. 13, p greater than 0.10). During the trial, different drug-induced changes were observed in serum lipids, glucose and uric acid. The importance of these changes are still uncertain.

Citations

Jan 1, 1992·International Journal of Technology Assessment in Health Care·M Johannesson
Sep 1, 1996·Journal of Nursing Management·M Skoberne
Apr 19, 2018·The Cochrane Database of Systematic Reviews·James M WrightRupam Gill
Aug 17, 2017·The Cochrane Database of Systematic Reviews·Vijaya M MusiniJames M Wright
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Jun 28, 2019·Journal of Hypertension·Susanne JungRoland E Schmieder
Dec 19, 2019·Kardiologiia·Ya A OrlovaE M Seredenina
Aug 17, 2012·The Cochrane Database of Systematic Reviews·Diana DiaoFrancois Gueyffier

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