Osmo-inelastic response of the intervertebral disc

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
Amil DerrouicheFahed Zaïri

Abstract

The intervertebral disc exhibits a complex inelastic response characterized by relaxation, hysteresis during cyclic loading and rate dependency. All these inelastic phenomena depend on osmotic interactions between disc tissues and their surrounding chemical environment. Coupling between osmotic and inelastic effects is not fully understood, so this article aimed to study the influence of chemical conditions on the inelastic behaviour of the intervertebral disc in response to different modes of loading. A total of 18 non-frozen 'motion segments' (two vertebrae and the intervening soft tissues) were dissected from the cervical spines of mature sheep. The motion segments were loaded in tension, compression and torsion at various loading rates and saline concentrations. Analysis of variance showed that saline concentration significantly influenced inelastic effects in tension and especially in compression (p < 0.05), but not in torsion. Opposite effects were seen in tension and compression. An interpretation of the underlying osmo-inelastic mechanisms is proposed in which two sources of inelastic effects are identified, that is, extracellular matrix rearrangements and fluid exchange created by osmosis.

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Citations

Jul 4, 2020·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Amil DerrouicheFahed Zaïri
Jun 6, 2019·Biomechanics and Modeling in Mechanobiology·Amil DerrouicheFahed Zaïri
Nov 11, 2020·Scientific Reports·Karim KandilFahed Zaïri
Nov 28, 2020·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Fahed ZaïriRégis Logier
Dec 16, 2020·Computer Methods and Programs in Biomedicine·Karim KandilFahed Zaïri

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