PMID: 6407333Jun 1, 1983Paper

Osmoregulation of thirst and vasopressin secretion in human subjects: effect of various solutes

The American Journal of Physiology
R L Zerbe, G L Robertson

Abstract

Various hypertonic solutions were infused in healthy human volunteers to determine their effect on thirst and vasopressin secretion. Hypertonic saline and mannitol produced prompt and parallel increases in plasma osmolality and vasopressin concentration. For both of these solutes, there was a high degree of correlation between these measurements. The slope describing this relationship varied considerably between individuals, but the same subjects showed similar slopes with either saline or mannitol. Both solutions stimulated thirst. Hypertonic urea infusions produced a comparable rise in osmolality but produced a smaller increase in plasma vasopressin and stimulated thirst in only one of the subjects. With urea, the correlation between plasma osmolality and vasopressin was significantly lower. Within individuals, the slope describing this relationship was significantly correlated with that seen during hypertonic saline. Hypertonic glucose significantly increased plasma osmolality but decreased plasma vasopressin and had no detectable effect on thirst. We conclude that osmoregulation of vasopressin in humans is mediated by a selective osmoreceptor that is located primarily outside of the blood-brain barrier and that individual d...Continue Reading

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Citations

Nov 5, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marcus May, Jens Jordan
Mar 27, 2020·Nutrients·Lawrence E ArmstrongElizabeth M Armstrong
Aug 5, 2004·American Journal of Physiology. Endocrinology and Metabolism·Amar AghaChristopher J Thompson
Mar 10, 2006·American Journal of Physiology. Renal Physiology·Dan ZhaoBaoxue Yang
May 25, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Junne-Ming SungJeng-Jong Huang
May 1, 2015·American Journal of Physiology. Renal Physiology·Lise BankirNadine Bouby
Sep 11, 2003·American Journal of Physiology. Renal Physiology·Lise BankirBaoxue Yang
Dec 20, 2018·Nutrients·Lawrence E Armstrong, Evan C Johnson
Jan 22, 2020·American Journal of Physiology. Renal Physiology·Clara Odilia SailerMirjam Christ-Crain
Aug 28, 2020·Nutrients·Lawrence E ArmstrongElaine C Lee
Apr 6, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·G H SchoorlemmerR L Thunhorst
Jan 24, 2004·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Michael J McKinley, Alan Kim Johnson
Apr 12, 2005·American Journal of Physiology. Renal Physiology·Baoxue Yang, Lise Bankir
Jan 1, 2010·American Journal of Physiology. Renal Physiology·Anita T LaytonHarold E Layton
Feb 6, 2018·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Mehmet Emin CeylanAlper Evrensel

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