Abstract
Hyposmolarity activates amino acid efflux as part of the corrective volume process in a variety of cells. This review discusses the mechanism of amino acid release in brain cells preparations. Results present evidence of substantial differences between the efflux of taurine and that of GABA and glutamate, which besides a possible role as osmolytes, have a main function as synaptic transmitters. The differences found concern the efflux time course, the sensitivity to C1- channel blockers, the modulation by tyrosine kinases, the influence of PKC and the effect of cytoskeleton disruptive agents. While taurine efflux features fit well with the mechanisms so far described in most cell types, the efflux of GABA and glutamate does not. Alternate mechanisms for the release of these two amino acids are discussed, including a PKC-modulated, actin-dependent exocytosis.
Citations
Jun 1, 2006·Acta Physiologica·A Stutzin, E K Hoffmann
Feb 27, 2008·Journal of Cellular Physiology·Rodrigo FrancoLenin D Ochoa de la Paz
Aug 30, 2008·Journal of Neuroscience Research·Jana BenesovaAlexander Chvatal
May 29, 2013·International Journal of Molecular Sciences·Maja PotokarRobert Zorec
May 15, 2015·Neurochemical Research·Anne M Maliszewski-HallRaghavendra Rao
Apr 3, 2020·Scientific Reports·Meilin ZhengJieying Gao
Feb 16, 2006·Journal of Neurochemistry·James E Olson, Eduardo Martinho
Mar 2, 2013·PloS One·Juan M FernándezClaudia Capurro
Mar 26, 2015·Cell Transplantation·Nina VardjanRobert Zorec
Nov 23, 2005·Journal of Neurochemistry·B Jill VentonRobert T Kennedy
Oct 13, 2006·Journal of Neurochemistry·Tina PangrsicMarko Kreft
May 19, 2010·Journal of Neurochemistry·Raghavendra RaoIvan Tkac
Mar 19, 2013·Glia·Maja PotokarRobert Zorec
Apr 13, 2011·The Journal of Comparative Neurology·M T BessonS Birman
Aug 3, 2006·Glia·Hong-Tao LiuRavshan Z Sabirov
Oct 17, 2008·American Journal of Physiology. Cell Physiology·Guangze Li, James E Olson
Dec 22, 2004·The Journal of Biological Chemistry·Marie Thérèse BessonSerge Birman
Jan 30, 2021·Frontiers in Cell and Developmental Biology·Yasunobu OkadaTomohiro Numata
Sep 20, 2008·Brain Research·Marie-Françoise RitzRamaroson Andriantsitohaina
May 14, 2003·Neurochemistry International·J W Phillis, M H O'Regan
Jan 27, 2005·Neurochemistry International·Tatyana V WaseemSergei V Fedorovich
Nov 3, 2016·Analytical Chemistry·Mark J HackettGraham N George
Apr 27, 2010·Neuroscience·J G Verbalis