PMID: 3745773Jul 1, 1986Paper

Osmosensitive vagal receptors in the small intestine of the cat

Journal of the Autonomic Nervous System
N Mei, L Garnier

Abstract

In anesthetized cats, the unitary activity of 66 sensory vagal neurones was recorded with extracellular glass microelectrodes implanted in the nodose ganglia. These neurones had non-medullated afferent fibres with conduction velocities between 0.8 and 1.2 m/s, as do most of the intestinal vagal fibres, and were silent or fired at low frequencies before any simulation. They were activated by perfusion of the small intestine (duodenum and first part of jejunum) with tap water and various solutions (glucose, NaCl and mannitol, in particular) having osmotic pressures ranged between 4 and 1100 mOsm. In general, hypotonic solutions and tap water induced the more marked responses, but differences were observed according to the solution used. Most of these neurones were also excited by other forms of stimulation including stroking of the mucosa and perfusion with warm (39-55 degrees C) and acid (HCl at pH 1) solutions. Therefore they must be considered to be polymodal receptors sensitive to osmotic pressure. The short latency of responses elicited by osmotic stimulations, the marked sensitivity to mucosal stroking and the disappearance of nervous activity after local anesthesia indicate that these receptors are located close to the epi...Continue Reading

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Citations

Jul 1, 1986·Journal of the Autonomic Nervous System·L GarnierJ Melone
Nov 1, 1986·Journal of the Autonomic Nervous System·J Mélone
Jan 1, 1991·Journal of the Autonomic Nervous System·X G ZhangW Renehan
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Nov 5, 2010·Biological & Pharmaceutical Bulletin·Tomokazu Tsurugizawa, Kunio Torii
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