Osmotic demyelination syndrome after correction of severe hyponatremia associated with pituitrin

International Journal of Clinical Pharmacology and Therapeutics
Dan Hua XuYun Zhen Hu

Abstract

Osmotic demyelination syndrome (ODS) may be precipitated by aggressive correction of a hypoosmolar state. We report the case of a 24-year-old woman who developed ODS during rapid correction of asymptomatic hyponatremia caused by pituitrin prescribed for hemoptysis. After hyponatremia correction by NaCl supplementation, the patient developed limb weakness, blurred vision, hand and perioral numbness, and lisp. Magnetic resonance imaging (MRI) revealed bilateral signal hyperintensity of the globus pallidus and caudate nucleus, compatible with extra-pontine ODS. These symptoms improved gradually with treatment, and brain MRI ~ 3 months later indicated substantial resolution of ODS. This case serves as a warning to physicians that hypoosmotic correction must be achieved at a controlled rate.

Citations

Sep 26, 2015·International Journal of Cardiology·Mehmet EyubogluAbdurrahman Arslan
Oct 23, 2016·Clinical Biochemistry·Bo WangWeixian Chen
Mar 2, 2021·Neurology India·Jie-Ping LuQi-Qiang Tang

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