PMID: 3756165Oct 9, 1986Paper

Osmotic water permeability and solute reflection coefficients of rat kidney brush-border membrane vesicles

Biochimica Et Biophysica Acta
J PratzB Corman

Abstract

Solute reflection coefficients, sigma i, of rat kidney brush-border membrane vesicles were determined by the comparison of water flows induced by equiosmolal gradients of sucrose and NaCl, KCl or mannitol. The values of 0.53 for sigma NaCl and 0.56 for sigma KCl when compared with 0.92 for sigma mannitol suggested some interactions between salt and water pathways. Altering the membrane proteins with 0.4 mM HgCl2 decreased the osmotic water permeability of the vesicles by 70 to 80% and brought sigma NaCl and sigma KCl to a value not different from 1. This argued in favor of water protein pathways in the luminal membrane of kidney proximal cells which are partly accessible to NaCl and KCl.

Citations

Jan 1, 1989·The International Journal of Biochemistry·R BéliveauJ Strévey
Nov 16, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J NeugartenB Kasiske
Mar 17, 2001·The Journal of Physiology·T ZeuthenD A Klaerke

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