Osseointegration in osteoporotic-like condition: A systematic review of preclinical studies

Journal of Periodontal Research
X DerekaNikos Mardas

Abstract

Osteoporosis is one of the most common skeletal disorders affecting a significant percentage of people worldwide. Research data suggested that systemic diseases such as osteoporosis could act as risk factors for osseointegration, jeopardizing the healing process and thus the predictability of dental implant success on compromised patients. It is well accepted that preclinical studies in animal models reproducing the osteoporotic condition are one of the most important stages in the research of new biomaterials and therapeutic modalities. The aim of this systematic review was to investigate whether osteoporosis compromises dental implant osseointegration in experimental osteoporotic-like conditions. A 3-stage systematic literature research was conducted in MEDLINE via OVID and EMBASE up to and including March 2017. Experimental studies reporting on dental implant osseointegration on different osteoporotic animal models were assessed. The studies had to report on the percentage of bone-to-implant contact (%BIC) as the primary outcome. ARRIVE guidelines for reporting on animal research were applied to evaluate the methodological quality and risk of bias of the studies. Fifty-seven studies met the inclusion criteria and were assess...Continue Reading

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Citations

Mar 17, 2020·Biomedical Engineering Letters·A L Overmann, J A Forsberg
Dec 31, 2020·International Journal of Oral and Maxillofacial Surgery·R TabriziB T Ozkan
Mar 6, 2021·Archives of Oral Biology·Bruna Barcelos SóManoela Domingues Martins
Jan 3, 2020·Archives of Oral Biology·Aline Tany PoschMarcelo Henrique Napimoga

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