Ossicular bone modeling in acute otitis media

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Rasmus Lysholdt SalomonsenP Cayé-Thomasen

Abstract

A number of middle ear diseases are associated with pathologic bone modeling, either formative or resorptive. As such, the pathogenesis of a sclerotic mastoid has been controversial for decades. Experimental studies on acute middle ear infection have shown progressive osteoneogenesis in the bone structures surrounding the middle ear cavity, and a few studies have reported acute changes of the ossicular chain. However, detailed qualitative and quantitative information on ossicular bone modeling dynamics has not been accounted for and is thus the purpose of this study. The histopathology of the middle ear bone tissue structures was studied longitudinally in a rat model of acute pneumococcal otitis media, from Days 1 to 28 postinoculation. Resorptive and formative activity was semiquantitated for the ossicles and the bone tissue structures surrounding the middle ear cavity. Qualitative and semiquantitative histopathology revealed initial osteoresorption, followed by increasing apposition of new bone in the middle ear cavity. Equivalently, the ossicular chain and joints were subject to initial resorption and subsequent new bone formation, but the changes occurred were delayed and to a far lesser extent. A single incident of acute o...Continue Reading

References

Nov 1, 1990·Acta Oto-laryngologica·M S SørensenM B Jørgensen
May 1, 1988·American Journal of Otolaryngology·A HermanssonS Hellström
Aug 1, 1970·Acta Oto-laryngologica·M Tos
May 20, 1999·The Laryngoscope·P Cayé-ThomasenK Prellner
May 29, 2001·Current Pharmaceutical Design·P J Kostenuik, V Shalhoub
May 1, 1957·The Journal of Laryngology and Otology·I FRIEDMANN
Jan 5, 2005·The Laryngoscope·Andreas F ZehnderMichael J McKenna
Sep 15, 2005·International Journal of Pediatric Otorhinolaryngology·Giedre RaustyteJens Thomsen

❮ Previous
Next ❯

Citations

Dec 3, 2014·Human Molecular Genetics·Jennifer C FuchsAbigail S Tucker
Apr 3, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Per Cayé-ThomasenJorge Spratley
Apr 3, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J Douglas SwartsBo Tideholm

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.