PMID: 20643011Jul 21, 2010Paper

Ossification of newly generated cartilage from the perichondrium of auricular cartilage grafted in rabbit tympanic bullae

Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale
Tzong-Yang Tu, An-Hung Yang

Abstract

This study was performed to evaluate the histologic changes in the regenerated cartilage in the previously established rabbit tympanic bullae obliteration model. Experimental study. Tertiary otolaryngology care centre. The histologic sections of grafted cartilage were examined 4 weeks and 2 and 4 months after surgery. The chondrogenesis and osteogenesis ratios indicated by the cross-sectional area ratios of the newly formed cartilage and bone to the originally grafted cartilage were calculated and compared. Remarkable neochondrogenesis from the perichondrium of grafted auricular cartilage was found shortly after surgery. New cartilage appeared from the preserved perichondrium at the end of 4 weeks. Some areas of rapid division, maturation, and hypertrophy of the chondrocytes in the new cartilage were noted 4 weeks to 2 months after surgery. A process resembling endochondral ossification by replacement of new cartilage with immature woven bone was observed 2 months postoperatively. The remodeling process that substituted the immature woven bone with mature lamellar bone was seen 4 months after grafting. The chondrogenesis and the osteogenesis ratios were significantly different at the ends of 4 weeks and 2 and 4 months (p < .05)...Continue Reading

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