Ostensibly ineffectual doses of cadmium and lipopolysaccharide causes liver damage in rats

Human & Experimental Toxicology
Periasamy SrinivasanMing-Yie Liu

Abstract

Various hepatotoxicants co-treated with lipopolysaccharide (LPS) have the potential to cause severe hepatic damage. Whether co-treatment with ostensibly ineffectual (without effect on customary clinical liver function tests, such as aspartate aminotransferase and alanine aminotransferase) doses of cadmium (Cd) and LPS cause liver damage is still unknown. We examined the effects of treating ostensibly ineffectual doses of Cd and LPS on liver dysfunction as well as on liver histopathology. We injected rats with saline only, Cd only, LPS only, or a single ostensibly ineffectual dose of Cd (100 μg/kg body weight) plus LPS (0.1 mg/kg body weight). After 6 h, the rats were killed and their liver damage was assessed. Co-treated with ostensibly ineffectual doses of Cd and LPS had higher levels of aspartate aminotransferase and alanine aminotransferase, hepatic lipid peroxidation, peroxynitrite, nitrite, and interleukin-1β (IL-1β), but lower levels of hepatic metallothionein (MT) than did that treated with saline only, Cd only, and LPS only. Histopathological analysis of Cd only and LPS only showed apparent liver damage, but Cd plus LPS showed marked hepatic damage. We conclude that co-treating the rats with ostensibly ineffectual doses...Continue Reading

References

May 1, 1974·Toxicology and Applied Pharmacology·J A CookN R Di Luzio
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·L C GreenS R Tannenbaum
Jul 29, 1994·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R M May
Oct 1, 1995·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·S SarkarD Bhatnagar
Mar 31, 2000·International Archives of Occupational and Environmental Health·M IkedaK Higashikawa
Mar 15, 2001·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·M NordbergH Basun
May 16, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Eric B Harstad, Curtis D Klaassen
Jan 7, 2004·Critical Care Medicine·Dur-Zong Hsu, Ming-Yie Liu
May 4, 2005·The Journal of Experimental Medicine·Charles A Dinarello
Jan 21, 2006·Molecular and Cellular Biochemistry·Ahmet KoyuAhmet Kocak
Mar 17, 2006·Human & Experimental Toxicology·M FilipicM Vudrag
Oct 27, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Silvina Mónica AlvarezMaría Sofía Giménez
Nov 16, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Manfred BilzerAlexander L Gerbes
Apr 25, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C Vicente-SánchezA I Morales
Oct 1, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·El Heni JihenKerkeni Abdelhamid

❮ Previous
Next ❯

Citations

Sep 18, 2015·International Journal of Environmental Research and Public Health·Seung Jin HanDae Jung Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Toxicology and Applied Pharmacology
J LiuC D Klaassen
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Swati N DesaiA V Ramachandran
Toxicology and Applied Pharmacology
P L Goering, C D Klaassen
Toxicology and Applied Pharmacology
R A SneedPatricia E Ganey
© 2021 Meta ULC. All rights reserved