Osteoarthritis may not be a one-way-road of cartilage loss--comparison of spatial patterns of cartilage change between osteoarthritic and healthy knees

Osteoarthritis and Cartilage
R Buck9001140 A investigators

Abstract

To explore whether longitudinal change in cartilage thickness in femorotibial subregions of knees with radiographic osteoarthritis (ROA) differs from that in healthy knees. 3T coronal magnetic resonance (MR) images were acquired in 152 women at seven clinical centers at baseline (BL) and 24 months. Knees from 75 women with signs of ROA in either anterior-posterior or Lyon schuss radiographs were compared with those from 77 asymptomatic healthy controls without ROA to identify knees showing greater change in cartilage thickness than expected based on observations in healthy knees. The femorotibial cartilage thickness was determined in BL and follow-up MR images across five tibial and three femoral subregions in the medial/lateral compartment, respectively. A substantial portion of knees with ROA were classified as having longitudinal cartilage thinning (28%) or thickening (20%) in at least one medial femorotibial subregion based on comparisons to longitudinal changes observed in healthy knees; only 5% showed both subregional thinning and thickening across (different) medial subregions at the same time. Whereas the estimated proportion of Kellgren Lawrence grade (KLG) 3 knees (n=28) with significant medial cartilage thinning (46%...Continue Reading

References

Jul 1, 1990·Statistics in Medicine·Y Hochberg, Y Benjamini
Feb 1, 1983·Annals of the Rheumatic Diseases·E VignonG Ville
Jul 27, 2001·Osteoarthritis and Cartilage·E CalvoG Herrero-Beaumont
Sep 5, 2002·Arthritis and Rheumatism·Anita E WlukaFlavia M Cicuttini
Jan 20, 2004·Arthritis and Rheumatism·F M CicuttiniS L Stuckey
Feb 20, 2004·Osteoarthritis and Cartilage·C G PeterfyH K Genant
Nov 1, 2006·NMR in Biomedicine·Felix EcksteinThomas M Link
Jul 27, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Felix EcksteinH Cecil Charles
Sep 1, 2007·Current Opinion in Rheumatology·Felix EcksteinDavid Hunter
Feb 20, 2008·Annals of the Rheumatic Diseases·F EcksteinUNKNOWN A9001140 Study Group
Apr 15, 2008·Annals of the Rheumatic Diseases·D J HunterUNKNOWN OAI Investigators
Jun 11, 2008·IEEE Transactions on Medical Imaging·Wolfgang Wirth, Felix Eckstein
Aug 9, 2008·Rheumatic Diseases Clinics of North America·David J Hunter, Marie-Pierre Hellio Le Graverand-Gastineau
Sep 16, 2008·Osteoarthritis and Cartilage·W WirthUNKNOWN OAI Investigator Group
Nov 1, 2008·Arthritis and Rheumatism·Felix EcksteinLeena Sharma

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Citations

Nov 3, 2011·Arthritis·Felix Eckstein, Wolfgang Wirth
May 6, 2014·Best Practice & Research. Clinical Rheumatology·Frank W RoemerAli Guermazi
Oct 10, 2013·Arthritis Care & Research·Sebastian CotofanaUNKNOWN Osteoarthritis Initiative Investigators
Apr 13, 2013·Journal of Magnetic Resonance Imaging : JMRI·Megan S CromerShih-Chang Wang
Feb 10, 2012·IEEE Transactions on Bio-medical Engineering·José G Tamez-PeñaSaara Totterman
Oct 4, 2014·Osteoarthritis and Cartilage·F EcksteinC G Miller
Mar 25, 2015·Current Opinion in Rheumatology·Shadpour DemehriJohn A Carrino
Oct 2, 2015·Cartilage·Yasuaki NakagawaTakashi Nakamura
Feb 6, 2013·The American Journal of Sports Medicine·Ans Van GinckelErik Witvrouw
Feb 25, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Julien FavreThomas P Andriacchi
May 2, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michael D NewtonTristan Maerz
Jun 28, 2017·Journal of Athletic Training·Randy J SchmitzSandra J Shultz
Apr 9, 2017·Annals of the Rheumatic Diseases·Garifallia SakellariouAnnamaria Iagnocco
Jan 10, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Tristan MaerzKevin C Baker
Dec 7, 2018·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Matthew S HarkeyJeffrey B Driban
Mar 5, 2019·La Radiologia medica·Tadashi OkanoFausto Salaffi
Mar 13, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Derek N PamukoffSteven A Garcia
May 20, 2020·Radiology·Frank W RoemerAli Guermazi
Apr 1, 2013·Cartilage·Dan R JørgensenErik B Dam
Sep 2, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Constance R ChuThomas P Andriacchi
Sep 9, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Claudia IriondoValentina Pedoia

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