Osteoarthritis year in review 2018: genetics and epigenetics.

Osteoarthritis and Cartilage
M A Jeffries

Abstract

This review was designed to identify highlights of the osteoarthritis (OA) genetics and epigenetics literature published between April 2017 and January 2018. A Pubmed literature search was conducted using the keywords 'osteoarthritis' and each of the following: 'genomic', 'genetic', 'epigenomic', 'epigenetic', 'histone', 'noncoding RNA', 'miRNA', 'lncRNA', 'DNA methylation', 'DNA hydroxymethylation', 'DNMT', and 'TET'. The dates of publication were restricted to 4/1/2017-1/15/2018. Results were compared to the same search terms limited to 4/1/2016-1/15/2017. Virtually all search term combinations demonstrated a decrease in papers published this year compared to last, with epigenetic and miRNA/lncRNA research being stable. Despite this, numerous advances were made this year, including the second large genome-wide association study (GWAS) study of hand OA, a new twin study of hip and knee OA concordance, an extensive study of GDF5 evolution, analyses of the contribution of Dnmt3a to OA, a description of DNA methylation in a nonhuman primate model of OA, and an integrated, multi-omics analysis of DNA methylation, mRNA, and protein expression in human OA samples, among others. A variety of micro- and a few circular-RNA studies were...Continue Reading

Citations

Jun 18, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Chen LiJi Qu
Nov 13, 2019·Rheumatology International·Antonio Miranda-DuarteJosé Manuel Rodríguez-Pérez
Jun 22, 2020·Journal of Cellular and Molecular Medicine·Xing-He XueYang Yang
Apr 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicola Volpi
Sep 20, 2020·Journal of Orthopaedic Surgery and Research·Hong YiWei Liu
Jun 27, 2020·Cell Death & Disease·Sunli HuJian Xiao
Jul 19, 2020·Clinical Rheumatology·Jian-Luo ZhangHong-Tao Yang
Dec 17, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Genevieve HousmanAnne C Stone
Aug 14, 2019·International Immunopharmacology·Yuangang WuYi Zeng
Mar 10, 2021·Bioscience, Biotechnology, and Biochemistry·Jian LiShui Sun
Sep 23, 2020·Non-coding RNA Research·He Chen, Ge Shan
Jun 8, 2021·Experimental and Therapeutic Medicine·Meng JiangJianping Cao
Oct 16, 2021·Experimental and Therapeutic Medicine·Zhengnan Li, Bojie Chen
Nov 24, 2021·Clinical Oral Investigations·Ryota TakaokaHiroaki Shimamoto

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