Osteoblast response to plasma-spray porous Ti6Al4V coating on substrates of identical alloy

Journal of Biomedical Materials Research. Part a
L SaldañaN Vilaboa

Abstract

We have evaluated the in-vitro biocompatibility of Ti6Al4V alloy coated by plasma spraying with an identical alloy. These surfaces are widely used in cementless prosthetic components, although osteoblasts behavior on this treated alloy has not been evaluated to date. Cross sectional examination revealed a thick and rough coating of identical composition without sign of delamination. Within the coating, small discontinuities and nonconnected pores were observed. Osteoblast response was evaluated by assessing cell adhesion, proliferation, and differentiation of primary cultures of human osteoblastic cells. Compared to the polished alloy, osteoblast adhesion measured as cell attachment and actin network reorganization was delayed on the plasma-sprayed surface. Cell proliferation and viability were also impaired on the rough surface. Several informative markers of osteoblastic differentiation such as procollagen I peptide, alkaline phosphatase, osteocalcin, osteoprotegerin, and mineralized nodule formation were evaluated and indicated that the plasma-sprayed alloy favored a more differentiated phenotype than polished alloy. Taken together, our in vitro results indicate that successful osseointegration of plasma spraying of Ti6Al4V ...Continue Reading

References

Jan 1, 1987·The Journal of Arthroplasty·M Spector
May 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M E MartínezP Esbrit
Dec 11, 1997·The Journal of Bone and Joint Surgery. British Volume·J R McLaughlin, K R Lee
Jan 16, 1998·Journal of Biomedical Materials Research·B D BoyanZ Schwartz
Oct 7, 1998·Clinical Oral Implants Research·S VercaigneJ A Jansen
Mar 18, 1999·Journal of Biomechanical Engineering·D M Brunette, B Chehroudi
Jun 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C H LohmannZ Schwartz
Jul 4, 2001·Medical Engineering & Physics·Y T SulT Albrektsson
Sep 5, 2002·Journal of Biomedical Materials Research·C H LohmannZ Schwartz
Sep 17, 2002·Calcified Tissue International·B D BoyanA L Boskey
Oct 16, 2002·The Journal of Bone and Joint Surgery. American Volume·Andreas LaupacisCindy Wong
Aug 27, 2003·Journal of Dental Research·L PostiglioneG Rossi
Jul 31, 2004·The Journal of Arthroplasty·Amanda D MarshallDavid R Mauerhan
Aug 5, 2004·Journal of Biomedical Materials Research. Part a·S LossdörferB D Boyan
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·Y T SulT Albrektsson
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·A WennerbergJ Lausmaa
Dec 18, 2004·Biomaterials·Weichang XueChuanxian Ding
Feb 11, 2005·Journal of Biomedical Materials Research. Part a·L SaldañaL Munuera

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Citations

Oct 5, 2007·Journal of Materials Science. Materials in Medicine·Yu Mi LeeHyun Wook Cho
Jan 25, 2012·Journal of Materials Science. Materials in Medicine·J C GalvánJ L González-Carrasco
Apr 9, 2009·Tissue Engineering. Part a·Yuncang LiCui'e Wen
Feb 14, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Majid Taghian Dehaghani, Mehdi Ahmadian
Apr 25, 2013·Journal of Biomedical Materials Research. Part a·Laura SaldañaNuria Vilaboa
Jun 10, 2009·Acta Biomaterialia·Xiaojian WangCui'e Wen
Jun 7, 2008·The Journal of Arthroplasty·Mark A KlaassenDelfino Carranza Guzman
Nov 20, 2013·Journal of Biomedical Materials Research. Part a·Hajime MinamikawaTakahiro Ogawa
Aug 14, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Henriette BretschneiderChristine Hofbauer

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