Osteoblastoma-like osteosarcoma: high-grade or low-grade osteosarcoma?

Histopathology
Marco GambarottiA Righi

Abstract

Osteoblastoma-like osteosarcoma is a rare variant of osteosarcoma (1% of all osteosarcomas), histologically similar to osteoblastoma. In the current World Health Organisation (WHO) classification, osteoblastoma-like osteosarcoma is classified within the group of conventional (high-grade) osteosarcomas. However, several published cases have been actually regarded as low-grade malignant tumours. As strict morphological criteria to distinguish between low- and high-grade lesions are not available, we reviewed our series of osteoblastoma-like osteosarcomas in the attempt to identify clinical and morphological features predictive of aggressiveness. We retrieved 15 cases of osteoblastoma-like osteosarcoma from the files of the Istituto Ortopedico Rizzoli. Patients received various treatments. Five patients developed metastasis and five patients developed local recurrences (all after incomplete surgery). Eleven patients were alive without disease, while four patients died of their disease. Statistical analysis revealed a statistically significant (P = 0.048) lower disease-free survival in patients with areas of conventional (high-grade) osteosarcoma. With the important limitation of a small cohort of patients, the presence of areas of...Continue Reading

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Citations

Sep 7, 2019·The American Journal of Surgical Pathology·Fernanda AmaryAdrienne M Flanagan
Feb 23, 2020·Der Pathologe·Albert RoessnerJohannes Haybäck
Jan 30, 2021·Virchows Archiv : an International Journal of Pathology·Kivilcim Eren ErdoganAngelo Paolo Dei Tos
Sep 21, 2020·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Ashutosh RathAnil Dhal
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May 30, 2021·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Michele FioreMassimiliano De Paolis
Aug 21, 2021·Current Pharmaceutical Design·Wen XuChengfu Yuan

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